DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P58IPK and DNAJC7

DIOPT Version :9

Sequence 1:	NP_649916.1	Gene:	P58IPK / 41161	FlyBaseID:	FBgn0037718	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_003306.3	Gene:	DNAJC7 / 7266	HGNCID:	12392	Length:	494	Species:	Homo sapiens

Alignment Length:	467	Identity:	117/467 - (25%)
Similarity:	204/467 - (43%)	Gaps:	25/467 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DIENHLELGKEFLARGQLSDALTHYHAAVEGDANNYLTLFKRGTVYLALGKTRFAVQDFSRVLEL 106
            :.|...|.|..:.|:...::|..:|..|::....|......|....:.||:.|.|:.|..:.:.|
Human    27 EAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRL 91

  Fly   107 KPDFMAARIQRGVVHMKSGEYEQAIQDFDQVLQEEPNNGLVLEHYSRLAPAQEQWVLVQQLIQYS 171
            ...|:...::.|..|:..|....|.:.|.:.|:.:..|....:.:.......|...:.:...:..
Human    92 DDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKR 156

  Fly   172 DHQNAIPMITQLLEISPWAVPFRQARSDAYIAINDPLLAIADLRQVNRLTQDSTEGHYKIAQLLY 236
            |.:..:..:.:.||.:|....|:..:::....:.....|.:....:.|:...:.:..|.....||
Human   157 DFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLY 221

  Fly   237 TIGHATNALKEIRECLKFDPEH-KLCFPFYK-KLRKVEKQLVNAEQAREEKHFAECIAAGEAVLR 299
            .......|::...:.|:..|:| |.|..... |..|.:|:  :..:|.:|.::..........|.
Human   222 YEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKE--DGNKAFKEGNYKLAYELYTEALG 284

  Fly   300 NEPEETMIRYEGHKVLCTCYTGDEQFGK---ALQQCKEALDIMKDAQV--YCDRADALLGTEMYD 359
            .:|....   ...|:.|...|.:.:..|   |::.|..|:. :.|..:  |..||...:.||.|:
Human   285 IDPNNIK---TNAKLYCNRGTVNSKLRKLDDAIEDCTNAVK-LDDTYIKAYLRRAQCYMDTEQYE 345

  Fly   360 DAIHSFQAALDLEESNTRAKEGIQRAKKLQ---KQSERRDYYKILGVKRSASKQEIVKAYRKAAQ 421
            :|:..::.....|    :.||..|..|..|   |:|:|:||||||||.::||:.||.|||||.|.
Human   346 EAVRDYEKVYQTE----KTKEHKQLLKNAQLELKKSKRKDYYKILGVDKNASEDEIKKAYRKRAL 406

  Fly   422 KWHPDNFRD---EEKKVAEKKFIDIAAAKEVLTDPEKRRQFDNGEDPLDPESNQRGGFHGEHPFG 483
            ..|||....   |.:|..||||.::..|..:|:||:|:.::|:|:| ||.|....|.|...:.|.
Human   407 MHHPDRHSGASAEVQKEEEKKFKEVGEAFTILSDPKKKTRYDSGQD-LDEEGMNMGDFDPNNIFK 470

  Fly   484 HFQHGSPFQFKF 495
            .| .|.|..|.|
Human   471 AF-FGGPGGFSF 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P58IPK	NP_649916.1	TPR_11	42..108	CDD:290150	15/65 (23%)
		TPR repeat	43..71	CDD:276809	7/27 (26%)
		TPR repeat	76..106	CDD:276809	7/29 (24%)
		TPR_11	78..142	CDD:290150	14/63 (22%)
		TPR repeat	111..139	CDD:276809	5/27 (19%)
		TPR_1	113..144	CDD:278916	6/30 (20%)
		TPR_19	167..234	CDD:291240	8/66 (12%)
		TPR repeat	190..220	CDD:276809	2/29 (7%)
		TPR repeat	225..253	CDD:276809	4/27 (15%)
		TPR repeat	309..337	CDD:276809	7/30 (23%)
		TPR_11	312..373	CDD:290150	15/65 (23%)
		TPR repeat	341..371	CDD:276809	8/31 (26%)
		TPR repeat	376..399	CDD:276809	10/25 (40%)
		DnaJ	395..>485	CDD:223560	41/92 (45%)
		DnaJ	396..460	CDD:278647	32/66 (48%)
DNAJC7	NP_003306.3	3a0801s09	19..>353	CDD:273380	62/331 (19%)
		TPR 1	28..61		7/32 (22%)
		TPR repeat	28..56	CDD:276809	7/27 (26%)
		TPR repeat	61..91	CDD:276809	7/29 (24%)
		TPR 2	62..95		7/32 (22%)
		TPR 3	96..129		6/32 (19%)
		TPR repeat	96..124	CDD:276809	5/27 (19%)
		TPR 4	142..175		5/32 (16%)
		TPR repeat	145..170	CDD:276809	1/24 (4%)
		TPR repeat	175..205	CDD:276809	2/29 (7%)
		TPR 5	177..209		3/31 (10%)
		TPR 6	210..243		6/32 (19%)
		TPR repeat	210..238	CDD:276809	4/27 (15%)
		PLN03088	253..>353	CDD:215568	22/105 (21%)
		TPR 7	256..289		6/34 (18%)
		TPR repeat	257..284	CDD:276809	4/28 (14%)
		TPR repeat	289..323	CDD:276809	7/37 (19%)
		TPR 8	294..327		8/33 (24%)
		TPR 9	328..361		8/36 (22%)
		TPR repeat	328..356	CDD:276809	7/27 (26%)
		DnaJ	380..>469	CDD:223560	40/89 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53711
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R325
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.880