DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P58IPK and DNAJC3

DIOPT Version :9

Sequence 1:	NP_649916.1	Gene:	P58IPK / 41161	FlyBaseID:	FBgn0037718	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_011519406.1	Gene:	DNAJC3 / 5611	HGNCID:	9439	Length:	533	Species:	Homo sapiens

Alignment Length:	517	Identity:	218/517 - (42%)
Similarity:	323/517 - (62%)	Gaps:	42/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VLLLLELFLEGAESTASPADIENHLELGKEFLARGQLSDALTHYHAAVEGDANNYLTLFKRGTVY 87
            :|:|::|..||||...: ||:|.||||||:.||.|||:|||:.:||||:||.:||:..::|.||:
Human    18 LLVLVDLQYEGAECGVN-ADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVF 81

  Fly    88 LALGKTRFAVQDFSRVLELKPDFMAARIQRGVVHMKSGEYEQAIQDFDQV--------------- 137
            ||:||::.|:.|.::|::||.||.|||:|||.:.:|.|:.::|..||.:|
Human    82 LAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVVFPVPSLLGLQRSLL 146

  Fly   138 --------------LQEEPNNGLVLEHYSRLAPAQEQWVLVQQLIQ---YSDHQNAIPMITQLLE 185
                          |:..|:.....|..|:|..:.|...|..|.:.   ..|:..||..:.::||
Human   147 DDLYLLFWFFLMKKLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILE 211

  Fly   186 ISPWAVPFRQARSDAYIAINDPLLAIADLRQVNRLTQDSTEGHYKIAQLLYTIGHATNALKEIRE 250
            :..|....|:.|::.:|...:|..||:||:..::|..|:||..|||:.|.|.:|....:|.|:||
Human   212 VCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRE 276

  Fly   251 CLKFDPEHKLCFPFYKKLRKVEKQLVNAEQAREEKHFAECIAAGEAVLRNEPEETMIRYEGHKVL 315
            |||.|.:||.||..||:::|:.|.:.:||:...:..:.:..:..|:|::.||..........:.:
Human   277 CLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERI 341

  Fly   316 CTCYTGDEQFGKALQQCKEALDIMKD-AQVYCDRADALLGTEMYDDAIHSFQAALDLEESNTRAK 379
            |.|::.||:..:|::.|.|.|.:..| .....|||:|.|..||||:||..::.|.:..|::.:.:
Human   342 CHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIR 406

  Fly   380 EGIQRAKKLQKQSERRDYYKILGVKRSASKQEIVKAYRKAAQKWHPDNFR-DEEKKVAEKKFIDI 443
            ||:::|::|.|||::|||||||||||:|.||||:|||||.|.:||||||: :||||.||||||||
Human   407 EGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDI 471

  Fly   444 AAAKEVLTDPEKRRQFDNGEDPLDPESNQRGG---FHGE----HPFGHFQHGSPFQFKFHFN 498
            |||||||:|||.|::||:||||||.||.|.||   ||..    ..|..|..|.||:||||||
Human   472 AAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P58IPK	NP_649916.1	TPR_11	42..108	CDD:290150	35/65 (54%)
		TPR repeat	43..71	CDD:276809	18/27 (67%)
		TPR repeat	76..106	CDD:276809	12/29 (41%)
		TPR_11	78..142	CDD:290150	27/92 (29%)
		TPR repeat	111..139	CDD:276809	12/56 (21%)
		TPR_1	113..144	CDD:278916	13/59 (22%)
		TPR_19	167..234	CDD:291240	21/69 (30%)
		TPR repeat	190..220	CDD:276809	8/29 (28%)
		TPR repeat	225..253	CDD:276809	13/27 (48%)
		TPR repeat	309..337	CDD:276809	7/27 (26%)
		TPR_11	312..373	CDD:290150	21/61 (34%)
		TPR repeat	341..371	CDD:276809	13/30 (43%)
		TPR repeat	376..399	CDD:276809	10/22 (45%)
		DnaJ	395..>485	CDD:223560	67/97 (69%)
		DnaJ	396..460	CDD:278647	50/64 (78%)
DNAJC3	XP_011519406.1	TPR_11	36..100	CDD:290150	34/63 (54%)
		TPR repeat	37..65	CDD:276809	18/27 (67%)
		TPR repeat	70..100	CDD:276809	12/29 (41%)
		TPR_11	73..132	CDD:290150	25/58 (43%)
		TPR repeat	105..132	CDD:276809	11/26 (42%)
		TPR_11	182..246	CDD:290150	17/63 (27%)
		TPR repeat	186..211	CDD:276809	5/24 (21%)
		TPR_11	216..281	CDD:290150	25/64 (39%)
		TPR repeat	216..246	CDD:276809	8/29 (28%)
		TPR repeat	251..279	CDD:276809	13/27 (48%)
		TPR repeat	285..309	CDD:276809	9/23 (39%)
		TPR repeat	330..364	CDD:276809	8/33 (24%)
		TPR_19	347..411	CDD:291240	22/63 (35%)
		TPR_1	369..402	CDD:278916	13/32 (41%)
		TPR repeat	369..397	CDD:276809	12/27 (44%)
		TPR repeat	403..426	CDD:276809	10/22 (45%)
		DnaJ	421..>527	CDD:223560	70/105 (67%)
		DnaJ	423..488	CDD:278647	50/64 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156746
Domainoid	1	1.000	108	1.000	Domainoid score	I6469
eggNOG	1	0.900	-	-		E2759_KOG0624
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2486
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1801
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53711
OrthoDB	1	1.010	-	-		D1106865at2759
OrthoFinder	1	1.000	-	-		FOG0004980
OrthoInspector	1	1.000	-	-		oto88825
orthoMCL	1	0.900	-	-		OOG6_101911
Panther	1	1.100	-	-	O	PTHR44140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R325
SonicParanoid	1	1.000	-	-		X2996
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840