DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P58IPK and dnajc7

DIOPT Version :9

Sequence 1:	NP_649916.1	Gene:	P58IPK / 41161	FlyBaseID:	FBgn0037718	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_009297610.1	Gene:	dnajc7 / 406579	ZFINID:	ZDB-GENE-040426-2483	Length:	522	Species:	Danio rerio

Alignment Length:	486	Identity:	113/486 - (23%)
Similarity:	210/486 - (43%)	Gaps:	50/486 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DIENHLELGKEFLARGQLSDALTHYHAAVEGDANNYLTLFKRGTVYLALGKTRFAVQDFSRVLEL 106
            :.|...|.|..:..:...::|...|..|::....|......|....:.|.:.|.|::|..:.:.|
Zfish    56 EAEGFKEQGNAYYVKKDYAEAFNFYTKAIDLCPKNASYYGNRAATLMMLSRYREALEDSQQAVRL 120

  Fly   107 KPDFMAARIQRGVVHMKSGEYEQAIQDFDQVLQEEPNNGLVLEHYSRLAPAQEQWVLVQQLIQYS 171
            ...||...::.|..|:..|....||:...:||:.||:|          :.||::....:.:::|.
Zfish   121 DDSFMKGHMREGKCHLLLGNAMAAIRCLQKVLEREPDN----------SQAQQEMKNAESILEYE 175

  Fly   172 ----------DHQNAIPMITQLLEISPWAVPFRQARSDAYIAIN---DPLLAIADLRQVNRLTQD 223
                      |.:..:..:.::|:.:.....|:..:::....:.   :.....:|:     |..|
Zfish   176 RMAEISFEKRDFRMVVFCMDRVLDSASACHRFKVLKAECLALLGRYPEAQSVASDI-----LRMD 235

  Fly   224 STEGH--YKIAQLLYTIGHATNALKEIRECLKFDPEHKLCFPFYKKLRKVEKQLVNAEQAREEKH 286
            ||.|.  |.....||.......|::...:.|:..|:|:......:..:.::.:.....:|.:|..
Zfish   236 STNGDALYVRGLCLYYEDCIDKAVQFFVQALRMAPDHEKARLACRNAKALKAKKEEGNKAFKEGS 300

  Fly   287 FAECIAAGEAVLRNEPEETMIRYEGHKVLCTCYTGDEQFGK---ALQQCKEALDIMKD-AQVYCD 347
            :.|........|..:|....   ...|:.|...|...:..|   |::.|.:|:.:.:. .:.|..
Zfish   301 YEEAYELYTEALTIDPNNIK---TNAKLYCNRATVGSKLNKLEQAIEDCTKAIKLDETYIKAYLR 362

  Fly   348 RADALLGTEMYDDAIHSFQAALDLEESNTRAKEGIQRAKKLQKQSERRDYYKILGVKRSASKQEI 412
            ||...:.||.|::|:..::.....|::... |..::.|:...|:|:|:||||:|||.::|::.||
Zfish   363 RAQCYMDTEQYEEAVRDYEKVYQTEKTKEH-KNLLKNAQLELKKSKRKDYYKVLGVDKNATEDEI 426

  Fly   413 VKAYRKAAQKWHPDNFRD---EEKKVAEKKFIDIAAAKEVLTDPEKRRQFDNGEDPLDPESNQ-- 472
            .|||||.|...|||....   |.:|..||||.::..|..||:||:|:.::|:|.|..|.:.|.
Zfish   427 KKAYRKRALMHHPDRHSGASAEVQKEEEKKFKEVGEAFTVLSDPKKKTRYDSGHDLEDDDMNMDF 491

  Fly   473 ------RGGFHGEHPFGHFQHGSPFQFKFHF 497
                  :..|.|...|. |:...|..|.|.|
Zfish   492 DANNIFKAFFGGPGGFS-FEASGPGNFFFQF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P58IPK	NP_649916.1	TPR_11	42..108	CDD:290150	13/65 (20%)
		TPR repeat	43..71	CDD:276809	6/27 (22%)
		TPR repeat	76..106	CDD:276809	6/29 (21%)
		TPR_11	78..142	CDD:290150	15/63 (24%)
		TPR repeat	111..139	CDD:276809	7/27 (26%)
		TPR_1	113..144	CDD:278916	9/30 (30%)
		TPR_19	167..234	CDD:291240	11/81 (14%)
		TPR repeat	190..220	CDD:276809	2/32 (6%)
		TPR repeat	225..253	CDD:276809	6/29 (21%)
		TPR repeat	309..337	CDD:276809	7/30 (23%)
		TPR_11	312..373	CDD:290150	14/64 (22%)
		TPR repeat	341..371	CDD:276809	7/30 (23%)
		TPR repeat	376..399	CDD:276809	7/22 (32%)
		DnaJ	395..>485	CDD:223560	39/100 (39%)
		DnaJ	396..460	CDD:278647	31/66 (47%)
dnajc7	XP_009297610.1	TPR_11	56..121	CDD:290150	12/64 (19%)
		TPR	57..90	CDD:197478	6/32 (19%)
		TPR repeat	57..85	CDD:276809	6/27 (22%)
		TPR_17	79..112	CDD:290167	7/32 (22%)
		TPR repeat	90..120	CDD:276809	6/29 (21%)
		TPR repeat	125..153	CDD:276809	7/27 (26%)
		TPR repeat	174..199	CDD:276809	2/24 (8%)
		TPR repeat	210..233	CDD:276809	1/27 (4%)
		TPR repeat	238..268	CDD:276809	6/29 (21%)
		TPR_11	286..354	CDD:290150	12/70 (17%)
		TPR repeat	286..313	CDD:276809	3/26 (12%)
		TPR repeat	318..352	CDD:276809	7/36 (19%)
		TPR_1	323..356	CDD:278916	7/32 (22%)
		TPR repeat	357..385	CDD:276809	7/27 (26%)
		DnaJ	409..>497	CDD:223560	36/87 (41%)
		DnaJ	410..477	CDD:278647	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53711
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850