DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P58IPK and SPBC543.02c

DIOPT Version :9

Sequence 1:	NP_649916.1	Gene:	P58IPK / 41161	FlyBaseID:	FBgn0037718	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_596790.1	Gene:	SPBC543.02c / 2541066	PomBaseID:	SPBC543.02c	Length:	476	Species:	Schizosaccharomyces pombe

Alignment Length:	486	Identity:	129/486 - (26%)
Similarity:	217/486 - (44%)	Gaps:	71/486 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GAESTASPADI-ENHLELGKEFLARGQLSDALTHYHAAVEGDANNYLTLF--KRGTVYLALGKTR 94
            |.||...||:: |....:|..|....:.::|:..|..|::..:::.|.::  .|...|:.:|:..
pombe    12 GTESQQEPAELAEKQKAIGNAFYKEKKYAEAIKAYTEAIDLGSDSALAIYYSNRAATYMQIGEFE 76

  Fly    95 FAVQDFSRVLELKPDF--MAARIQRGVVHMKSGEYE-QAIQDFDQVLQEEPNNGLVLEHYSRLAP 156
            .|:.|..:...:|||.  ..:||::.        || .:|.:..:|..:....||.|....||
pombe    77 LALCDAKQSDRIKPDVPKTQSRIRQA--------YEGLSILNEAEVYLKNKQAGLALNALDRL-- 131

  Fly   157 AQEQWVLVQQLIQYSDHQNAIPMITQLLEISPWAVPFRQARSDAYIAINDPLLAIADLRQVNRLT 221
                             |..|...||    .|.:..:.:|:  .||..||...|......|.||.
pombe   132 -----------------QRRIDSTTQ----PPMSWMYLKAQ--VYIFQNDMDRAQKIAHDVLRLN 173

  Fly   222 QDSTEGHYKIAQLLYTIGHATNALKEIRECLKFDPEHKLCFPFYKKLRKVEKQLVNAEQAREEKH 286
            ..:.|......:::|..|....|:...:|.||.||:.......:|::||:|...........:.:
pombe   174 PKNVEALVLRGKVMYYSGENAKAITHFQEALKLDPDCTTAKTLFKQVRKLENTKNQGNDLFRQGN 238

  Fly   287 FAECIAAGEAVLRNEPE--ETMIRYEGHK--VLCTCYTGDEQFGKALQQCKEALDI----MKDAQ 343
            :.:........|:.:|:  ||:.:...::  ||......:|    ||.....||.|    :|..:
pombe   239 YQDAYEKYSEALQIDPDNKETVAKLYMNRATVLLRLKRPEE----ALSDSDNALAIDSSYLKGLK 299

  Fly   344 VYCDRADALLGTEMYDDAIHSFQAALDLEESNTRAKEGIQRAKKLQKQSERRDYYKILGVKRSAS 408
            |   ||.|....|.:::|:...|:|::|:.|:...::.::|.:...|:|:|:|:||||||.:.|:
pombe   300 V---RAKAHEALEKWEEAVRDVQSAIELDASDANLRQELRRLQLELKKSKRKDHYKILGVSKEAT 361

  Fly   409 KQEIVKAYRKAAQKWHPDNFRDEEKKVAEKKFIDIAAAKEVLTDPEKRRQFDNGED--------- 464
            ..||.|||||.|..:|||  ::.....||.:|.::..|..:|:|||.||:||:|.|
pombe   362 DIEIKKAYRKLALVYHPD--KNAGNLEAEARFKEVGEAYTILSDPESRRRFDSGVDLEPGMEGGA 424

  Fly   465 PLDP----ESNQRGGFH--GEHPFGHFQHGS 489
            .:||    .:.|.||..  |..|.|.|..||
pombe   425 GMDPFDILRAYQAGGSFPGGGFPGGGFPGGS 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P58IPK	NP_649916.1	TPR_11	42..108	CDD:290150	12/68 (18%)
		TPR repeat	43..71	CDD:276809	6/28 (21%)
		TPR repeat	76..106	CDD:276809	6/31 (19%)
		TPR_11	78..142	CDD:290150	15/68 (22%)
		TPR repeat	111..139	CDD:276809	6/28 (21%)
		TPR_1	113..144	CDD:278916	6/31 (19%)
		TPR_19	167..234	CDD:291240	15/66 (23%)
		TPR repeat	190..220	CDD:276809	7/29 (24%)
		TPR repeat	225..253	CDD:276809	5/27 (19%)
		TPR repeat	309..337	CDD:276809	6/29 (21%)
		TPR_11	312..373	CDD:290150	18/66 (27%)
		TPR repeat	341..371	CDD:276809	8/29 (28%)
		TPR repeat	376..399	CDD:276809	5/22 (23%)
		DnaJ	395..>485	CDD:223560	41/104 (39%)
		DnaJ	396..460	CDD:278647	29/63 (46%)
SPBC543.02c	NP_596790.1	TPR_11	23..90	CDD:290150	12/66 (18%)
		TPR repeat	23..51	CDD:276809	6/27 (22%)
		TPR_1	29..52	CDD:278916	5/22 (23%)
		TPR repeat	56..88	CDD:276809	6/31 (19%)
		TPR repeat	93..117	CDD:276809	6/31 (19%)
		TPR repeat	146..171	CDD:276809	7/26 (27%)
		TPR_11	147..208	CDD:290150	16/62 (26%)
		TPR_11	176..254	CDD:290150	14/77 (18%)
		TPR_2	177..210	CDD:285020	9/32 (28%)
		TPR repeat	177..205	CDD:276809	5/27 (19%)
		TPR	227..256	CDD:197478	2/28 (7%)
		TPR repeat	227..251	CDD:276809	0/23 (0%)
		TPR repeat	256..290	CDD:276809	9/37 (24%)
		TPR_11	261..325	CDD:290150	17/70 (24%)
		TPR repeat	295..323	CDD:276809	9/30 (30%)
		DnaJ	348..>430	CDD:223560	35/83 (42%)
		DnaJ	349..411	CDD:278647	29/63 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53711
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R325
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950