DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF623

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_055604.3	Gene:	ZNF623 / 9831	HGNCID:	29084	Length:	536	Species:	Homo sapiens

Alignment Length:	515	Identity:	141/515 - (27%)
Similarity:	212/515 - (41%)	Gaps:	79/515 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEE 161
            |.:.|..:|      ..|.:.||     ..:|.:...:.|.||.:.:.       |....|.||.
Human     5 SFVSDSNVG------TGEKKVTE-----AWISEDENSHRTTSDRLTVM-------ELPSPESEEV 51

  Fly   162 QQQQYDEEVEEPITDE--SAP------PQLTISY-------ACKFCLRPQENYQLQQLLL----E 207
            .:.:..|.:..|....  |:|      .|:|:::       ..:.|.:...|:.|...||    |
Human    52 HEPRLGELLGNPEGQSLGSSPSQDRGCKQVTVTHWKIQTGETAQVCTKSGRNHILNSDLLLLQRE 116

  Fly   208 HINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSE 272
            .|....:|     |..|...|...:....|..|...||.:.|..|||.:|...:|..|...:..|
Human   117 LIEGEANP-----CDICGKTFTFNSDLVRHRISHAGEKPYTCDQCGKGFGQSSHLMEHQRIHTGE 176

  Fly   273 TDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEH 337
            ..:.|.:|.|.|.....|..|.:.|:.::.|||  :.|.:.|.....|:.|:..|  |..|..|
Human   177 RLYVCNVCGKDFIHYSGLIEHQRVHSGEKPFKC--AQCGKAFCHSSDLIRHQRVH--TRERPFE- 236

  Fly   338 CGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECML 402
            |..|||.|.....|..| .|.|.||:||:|..|.:.|.     |...|.||.:..|.:::.||..
Human   237 CKECGKGFSQSSLLIRH-QRIHTGERPYECNECGKSFI-----RSSSLIRHYQIHTEVKQYECKE 295

  Fly   403 CRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERH 467
            |.:.|....|||.|......:||                       |:|..|.:.|...|.|.:|
Human   296 CGKAFRHRSDLIEHQRIHTGERP-----------------------FECNECGKAFIRSSKLIQH 337

  Fly   468 AAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLE 532
            ..:|: .:||:.|..|.|||.:..:...|.:.|..||...|:.|||||.|...|.:|:..| ..|
Human   338 QRIHT-GERPYVCNECGKRFSQTSNFTQHQRIHTGEKLYECNECGKAFFLSSYLIRHQKIH-TGE 400

  Fly   533 KNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            :.::|..||:|:|.:..|..||:.|:|...::|..|.:.|:...||..| |..|...:|:
Human   401 RVYECKECGKAFLQKAHLTEHQKIHSGDRPFECKDCGKAFIQSSKLLLH-QIIHTGEKPY 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/313 (29%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF623	NP_055604.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..77		4/19 (21%)
		COG5048	123..494	CDD:227381	114/379 (30%)
		C2H2 Zn finger	125..145	CDD:275368	4/19 (21%)
		C2H2 Zn finger	153..173	CDD:275368	7/19 (37%)
		C2H2 Zn finger	181..201	CDD:275368	6/19 (32%)
		C2H2 Zn finger	209..229	CDD:275368	5/21 (24%)
		C2H2 Zn finger	237..257	CDD:275368	8/20 (40%)
		C2H2 Zn finger	265..285	CDD:275368	7/24 (29%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	7/20 (35%)
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100