DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF264

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_003408.1	Gene:	ZNF264 / 9422	HGNCID:	13057	Length:	627	Species:	Homo sapiens

Alignment Length:	558	Identity:	153/558 - (27%)
Similarity:	223/558 - (39%)	Gaps:	123/558 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EIGQEDLEPAEE-HQET--------ETTKPTTTVSA----------ETQPNNTASDPIEIFVDAV 148
            |.|||.....|: .|:|        :||:|||...|          .||.|:..|
Human    67 EHGQEPWTRKEDLSQDTCPGDKGKPKTTEPTTCEPALSEGISLQGQVTQGNSVDS---------- 121

  Fly   149 DIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLT-----ISYACKFCLR-PQENYQLQQLLLE 207
            .:.:||:::...|.|:.:.....:|  .|.:|.:::     :..|...|.| .||.......:..
Human   122 QLGQAEDQDGLSEMQEGHFRPGIDP--QEKSPGKMSPECDGLGTADGVCSRIGQEQVSPGDRVRS 184

  Fly   208 H--INASHDP-----EQPYNCPECEARFQDAASRTVHLKSSHVEKQHA------CGVCGKKY-GD 258
            |  ..:..||     |..:.|.||...|...     ||.:.| ||.|:      |..|||.: ..
Human   185 HNSCESGKDPMIQEEENNFKCSECGKVFNKK-----HLLAGH-EKIHSGVKPYECTECGKTFIKS 243

  Fly   259 RHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMC 322
            .|.|:||:  .|: |..:||..|.|.|..:..|..|.:.|:.::.:||..  |.:.|..:.:.:.
Human   244 THLLQHHM--IHTGERPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCNE--CGKAFTHRSNFVL 304

  Fly   323 HEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLER 387
            |...|:|   .||..|..||:.|.|......| |..|.||.||:|..|.:||     |....|..
Human   305 HNRRHTG---EKSFVCTECGQVFRHRPGFLRH-YVVHSGENPYECLECGKVF-----KHRSYLMW 360

  Fly   388 HRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCG 452
            |::..|..:..||..|.:.|.....||||......::|                       |:|.
Human   361 HQQTHTGEKPYECSECGKVFLESAALIHHYVIHTGEKP-----------------------FECL 402

  Fly   453 SCSQRFNMKSALERHAAVHS-EK--------------------------DRPHACPHCSKRFKRA 490
            .|.:.||.:|.|:||..:|: ||                          ::|..|..|.|.|...
Human   403 ECGKAFNHRSYLKRHQRIHTGEKPFVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNR 467

  Fly   491 QDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQR 555
            :|:..|...|..|||..|..|||||.....||:|:..|.. ||.::|..||:::.:..:|..|..
Human   468 KDLIRHFSIHTGEKPYECVECGKAFTRMSGLTRHKRIHSG-EKPYECVECGKSFCWSTNLIRHAI 531

  Fly   556 THTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHS 593
            .|||:..|||..|.:.|.....|..| |:.|....|.|
Human   532 IHTGEKPYKCSECGKAFSRSSSLTQH-QRMHTGKNPIS 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	93/351 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	8/20 (40%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	4/21 (19%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF264	NP_003408.1	KRAB	14..74	CDD:214630	4/6 (67%)
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..155		20/92 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..194		2/19 (11%)
		COG5048	184..568	CDD:227381	123/427 (29%)
		C2H2 Zn finger	205..225	CDD:275368	9/25 (36%)
		zf-H2C2_2	221..240	CDD:290200	8/19 (42%)
		C2H2 Zn finger	233..253	CDD:275368	8/21 (38%)
		zf-H2C2_2	245..270	CDD:290200	11/26 (42%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		zf-H2C2_2	273..298	CDD:290200	7/26 (27%)
		C2H2 Zn finger	289..309	CDD:275368	4/21 (19%)
		C2H2 Zn finger	317..337	CDD:275368	7/20 (35%)
		zf-C2H2	343..365	CDD:278523	8/26 (31%)
		C2H2 Zn finger	345..365	CDD:275368	7/24 (29%)
		zf-H2C2_2	357..380	CDD:290200	6/22 (27%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		zf-C2H2	399..421	CDD:278523	9/21 (43%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		zf-H2C2_2	413..438	CDD:290200	6/24 (25%)
		C2H2 Zn finger	429..449	CDD:275368	0/19 (0%)
		zf-H2C2_2	445..466	CDD:290200	5/20 (25%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		zf-H2C2_2	469..494	CDD:290200	12/24 (50%)
		C2H2 Zn finger	485..505	CDD:275368	9/19 (47%)
		zf-H2C2_2	498..520	CDD:290200	9/22 (41%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	525..550	CDD:290200	10/24 (42%)
		C2H2 Zn finger	541..561	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100