DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF670

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_149990.1	Gene:	ZNF670 / 93474	HGNCID:	28167	Length:	389	Species:	Homo sapiens

Alignment Length:	521	Identity:	114/521 - (21%)
Similarity:	174/521 - (33%)	Gaps:	180/521 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQY 166
            |.:..||:..|...:|.....|       :|.|.......|||.:...:....|::.
Human     2 DSVSFEDVAVAFTQEEWALLDP-------SQKNLYRDVMQEIFRNLASVGNKSEDQN-------- 51

  Fly   167 DEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECE---ARF 228
                   |.|:...|...:|                         ||..|:.:...|..   ..|
Human    52 -------IQDDFKNPGRNLS-------------------------SHVVERLFEIKEGSQYGETF 84

  Fly   229 QDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRK----- 288
            ...::..::.|.|...|...|.||||.:.....|..|:..:.....|||..|.::.|..|
Human    85 SQDSNLNLNKKVSTGVKPCECSVCGKVFICHSALHRHILSHIGNKLFECEECPEKLYHCKQCGKA 149

  Fly   289 -----SLNYHMKWHNP----------------------------DRQFKCRHSGCERLFISQRHL 320
                 |::.||..|..                            ::.:||:|  |::.|....:|
Human   150 FISLTSVDRHMVTHTSNGPYKGPVYEKPFDFPSVFQMPQSTYTGEKTYKCKH--CDKAFNYSSYL 212

  Fly   321 MCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHML 385
            ..||.||:|   .|...|..|||:|....:||.| .|.|.|||||:|..|.:.|:......||
Human   213 REHERTHTG---EKPYACKKCGKSFTFSSSLRQH-ERSHTGEKPYECKECGKAFSRSTYLGIH-- 271

  Fly   386 ERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQ 450
                                                                    ||.::|
Human   272 --------------------------------------------------------ERTHTG--- 277

  Fly   451 CGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAF 515
                                    ::|:.|..|.|.|:.::.::.|.:||..|||..|..|||||
Human   278 ------------------------EKPYECIKCGKAFRCSRVLRVHERTHSGEKPYECKQCGKAF 318

  Fly   516 ALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKT 580
            .....|.:|..:|..: |.:.|..||:::....:||.|:|||||:..|:|..|.:.|.....|:.
Human   319 KYSSNLCEHERTHTGV-KPYGCKECGKSFTSSSALRSHERTHTGEKPYECKKCGKAFSCSSSLRK 382

  Fly   581 H 581
            |
Human   383 H 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	71/350 (20%)
		C2H2 Zn finger	221..241	CDD:275368	3/22 (14%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/29 (24%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	0/19 (0%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/17 (29%)
ZNF670	NP_149990.1	KRAB	3..44	CDD:307490	10/47 (21%)
		C2H2 Zn finger	81..97	CDD:275368	2/15 (13%)
		C2H2 Zn finger	105..125	CDD:275368	7/19 (37%)
		C2H2 Zn finger	143..163	CDD:275368	4/19 (21%)
		C2H2 Zn finger	199..219	CDD:275368	7/21 (33%)
		COG5048	<223..384	CDD:227381	62/248 (25%)
		C2H2 Zn finger	227..247	CDD:275368	9/20 (45%)
		C2H2 Zn finger	255..275	CDD:275368	7/77 (9%)
		C2H2 Zn finger	283..303	CDD:275368	5/19 (26%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..385	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100