DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF461

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_694989.2	Gene:	ZNF461 / 92283	HGNCID:	21629	Length:	563	Species:	Homo sapiens

Alignment Length:	518	Identity:	135/518 - (26%)
Similarity:	211/518 - (40%)	Gaps:	120/518 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 NNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDE---SAPPQLTISYA-----CK 190
            ||.|:|     ::| |:...:|.::...::..|:.|:.:.:..|   |..|:.:|..|     |.
Human    92 NNEATD-----INA-DLASRDEPQKLSPKRDIYETELSQWVNMEEFKSHSPERSIFSAIWEGNCH 150

  Fly   191 F-CLRPQENYQLQQLLLEHINAS------------HDPEQPYNCPECEARFQDAASRTVHLKSSH 242
            | ..:.||....:||::.|.|..            :|.|:...|.:|...|      :.||..||
Human   151 FEQHQGQEEGYFRQLMINHENMPIFSQHTLLTQEFYDREKISECKKCRKIF------SYHLFFSH 209

  Fly   243 VEKQHA--------------------------------CGVCGKKYGDRHNLRHHVEKYHSETDF 275
            .::.|:                                |..|.|.:.....|: |:..::.|..:
Human   210 HKRTHSKELSECKECTEIVNTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLK-HLRIHNGEKRY 273

  Fly   276 ECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGF 340
            ||..|.|.|.....|..|.:.|..::.::|:.  |.:.|..:..|..|:..|:|   .|...|..
Human   274 ECNECGKAFNYGSELTLHQRIHTGEKPYECKE--CGKAFRQRSQLTQHQRLHTG---EKPYECKQ 333

  Fly   341 CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIER-------S 398
            |||.||....|..|: |.|.|||||:|..|.:.|            |||.:||..:|       .
Human   334 CGKAFIRGFQLTEHL-RLHTGEKPYECKECGKTF------------RHRSHLTIHQRIHTGEKPY 385

  Fly   399 ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSA 463
            ||..|.:.||......||......::|                       ::|..|.:.|.....
Human   386 ECRECGKAFSYHSSFSHHQKIHSGKKP-----------------------YECHECGKAFCDGLQ 427

  Fly   464 LERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH 528
            |..|..:|: .::|:.|..|.|.|::...:|.|.:.|..|||:.|.:|||||.|...|.||:..|
Human   428 LTLHQRIHT-GEKPYECKECGKTFRQCSHLKRHQRIHTGEKPHECMICGKAFRLHSHLIQHQRIH 491

  Fly   529 EVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
             ..||.::|..||:|:.:..|...|||.|:||..|:|.   :.|...::|..| |..|...:|
Human   492 -TGEKPYECKECGKAFSYHSSFSHHQRIHSGKKPYQCG---KAFNHRLQLNLH-QTLHTGEKP 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/360 (24%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF461	NP_694989.2	KRAB	6..66	CDD:214630
		C2H2 Zn finger	248..267	CDD:275368	5/19 (26%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..312	CDD:316026	6/26 (23%)
		C2H2 Zn finger	303..323	CDD:275368	5/21 (24%)
		COG5048	<312..515	CDD:227381	72/243 (30%)
		C2H2 Zn finger	331..351	CDD:275368	9/20 (45%)
		C2H2 Zn finger	359..379	CDD:275368	9/31 (29%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		C2H2 Zn finger	471..491	CDD:275368	10/19 (53%)
		C2H2 Zn finger	499..519	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..544	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100