DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF765

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001035275.1	Gene:	ZNF765 / 91661	HGNCID:	25092	Length:	523	Species:	Homo sapiens

Alignment Length:	507	Identity:	137/507 - (27%)
Similarity:	203/507 - (40%)	Gaps:	112/507 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEI---FVDAVDIDEAEEEEEEEEQQQQYD 167
            |||.....|...|:..|.|.:.....| |...:.|::.   |.....:.|......||    :.|
Human   102 QEDERNGHEALMTKIKKLTGSTERYDQ-NYAGNKPVKYQLGFSFHSHLPELHIFHTEE----KID 161

  Fly   168 EEVEEPITDESAPPQLTISYACKFCLRPQ--------ENY-------QLQQL-LLEHINASHDPE 216
            .:|.:.|.|.|     .:|.|.:...||:        .|:       |.|:: :.|.....:|..
Human   162 NQVVKSIHDAS-----LVSTAQRISCRPETHISNDYGNNFLNSSLFTQKQEVHMREKSFQCNDSG 221

  Fly   217 QPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCE 281
            :.|||.....:.|     .:||.    |||:.|.:|||.:..:..:..|...:..|..::|..|.
Human   222 KAYNCSSLLRKHQ-----LIHLG----EKQYKCDICGKVFNSKRYVARHRRCHTGEKPYKCNECG 277

  Fly   282 KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFI 346
            |.|.....|..|.:.|..::.:||..  |::.|..:..|..|...|:|   .|...|..|||||.
Human   278 KTFSQTYYLTCHRRLHTGEKPYKCEE--CDKAFHFKSKLQIHRRIHTG---EKPYKCNECGKTFS 337

  Fly   347 HLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            ....|..| .|.|.|||||||..|.:.|:    ::.|....||
Human   338 QKSYLTCH-RRLHTGEKPYKCNECGKTFS----RKSHFTCHHR---------------------- 375

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDR 476
              :|                        ..|:.|    :|..||:.|:.||:|..|..:|:| ::
Human   376 --VH------------------------TGEKPY----KCNECSKTFSHKSSLTYHRRLHTE-EK 409

  Fly   477 PHACPHCSKRFKRAQDMKWHI-KTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKN-FKCNV 539
            |:.|..|.|.|.  |.:..:| :.|..|||..|:.|.||::.|..|..|:..|  .|:| :|||.
Human   410 PYKCNECGKTFN--QQLTLNICRLHSGEKPYKCEECDKAYSFKSNLEIHQKIH--TEENPYKCNE 470

  Fly   540 CGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHM-----QKAH 586
            ||:.:....||..|.|.|||:..|||:.|.|.|.....|:.|.     :|.|
Human   471 CGKTFSRTSSLTYHHRLHTGQKPYKCEDCDEAFSFKSNLERHRRIYTGEKLH 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	82/318 (26%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	1/19 (5%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	6/20 (30%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF765	NP_001035275.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368	5/24 (21%)
		zf-H2C2_2	230..254	CDD:290200	10/32 (31%)
		C2H2 Zn finger	245..265	CDD:275368	5/19 (26%)
		zf-H2C2_2	260..282	CDD:290200	6/21 (29%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		zf-H2C2_2	285..309	CDD:290200	6/25 (24%)
		C2H2 Zn finger	301..321	CDD:275368	5/21 (24%)
		zf-H2C2_2	314..338	CDD:290200	11/26 (42%)
		COG5048	<325..477	CDD:227381	62/213 (29%)
		C2H2 Zn finger	329..349	CDD:275368	9/20 (45%)
		zf-H2C2_2	341..366	CDD:290200	13/29 (45%)
		C2H2 Zn finger	357..377	CDD:275368	6/47 (13%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	9/27 (33%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		zf-H2C2_2	452..477	CDD:290200	10/26 (38%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		C2H2 Zn finger	496..515	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100