DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF251

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_612376.1	Gene:	ZNF251 / 90987	HGNCID:	13045	Length:	671	Species:	Homo sapiens

Alignment Length:	472	Identity:	131/472 - (27%)
Similarity:	190/472 - (40%)	Gaps:	61/472 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 ASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEP-------ITDESAPPQLTISYACKFCLR 194
            |.:| :|........|...::|.....|::.|||:.|       :.|.:...:...::..:..|:
Human    81 AEEP-DILKSCQKDSEVGTKKELSILNQKFSEEVKTPEFVSRRLLRDNAQAAEFREAWGREGKLK 144

  Fly   195 PQENYQLQQLL---------LEHINASHDPEQPYNCPECEA--RFQDAASRTVHLKSSHV-EKQH 247
            .:......|.|         |.......:........||.|  |..:.....|.|:.:.. |:..
Human   145 ERVGNSAGQSLNKPNIHKRVLTEATVGRERSLGERTQECSAFDRNLNLDQNVVRLQRNKTGERVF 209

  Fly   248 ACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCER 312
            .|.:|.|.:....:|..|...:..|..:||..|.:.|....:|..|...|..::.|||  ..|.:
Human   210 KCDICSKTFKYNSDLSRHQRSHTGEKPYECGRCGRAFTHSSNLVLHHHIHTGNKPFKC--DECGK 272

  Fly   313 LFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASY 377
            .|....||..|...|:|   .|...||.|||.|....||..|.. .|.|||||||..|...|:..
Human   273 TFGLNSHLRLHRRIHTG---EKPFGCGECGKAFSRSSTLIQHRI-IHTGEKPYKCNECGRGFSQS 333

  Fly   378 AEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRE 442
            .:     |.:|:...|..:..||..|.:.||....||.|                         |
Human   334 PQ-----LTQHQRIHTGEKPHECSHCGKAFSRSSSLIQH-------------------------E 368

  Fly   443 RQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKP 505
            |.::|  ..:|..|.:.|:..|:|..|..||: .::|:.|..|.:.|.....:..|::.|..|||
Human   369 RIHTGEKPHKCNQCGKAFSQSSSLFLHHRVHT-GEKPYVCNECGRAFGFNSHLTEHVRIHTGEKP 432

  Fly   506 NVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQE 570
            .||:.|||||.....|.|||..| ..||.::|..||:|:.....|.||||.|||:..|.|..|.:
Human   433 YVCNECGKAFRRSSTLVQHRRVH-TGEKPYQCVECGKAFSQSSQLTLHQRVHTGEKPYDCGDCGK 496

  Fly   571 RFVTHIKLKTHMQKAHA 587
            .|.....|..| ||.|:
Human   497 AFSRRSTLIQH-QKVHS 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/323 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/21 (29%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF251	NP_612376.1	KRAB	15..75	CDD:214630
		C2H2 Zn finger	181..203	CDD:275368	6/21 (29%)
		COG5048	207..635	CDD:227381	109/345 (32%)
		C2H2 Zn finger	211..231	CDD:275368	5/19 (26%)
		C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		C2H2 Zn finger	267..287	CDD:275368	6/21 (29%)
		C2H2 Zn finger	295..315	CDD:275368	9/20 (45%)
		C2H2 Zn finger	323..343	CDD:275368	5/24 (21%)
		C2H2 Zn finger	351..371	CDD:275368	9/44 (20%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		C2H2 Zn finger	407..427	CDD:275368	4/19 (21%)
		C2H2 Zn finger	435..455	CDD:275368	10/19 (53%)
		C2H2 Zn finger	463..483	CDD:275368	9/19 (47%)
		C2H2 Zn finger	491..511	CDD:275368	7/20 (35%)
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	596..616	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100