DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF160

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	419	Identity:	134/419 - (31%)
Similarity:	190/419 - (45%)	Gaps:	31/419 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            |.|..|   .:.:.....|..| ...|..|:||.|.||...|...::.|:|......||.:.|..
Human   257 YKCNEC---GKAFTQNSNLTSH-RRIHSGEKPYKCSECGKTFTVRSNLTIHQVIHTGEKPYKCHE 317

  Fly   252 CGKKYGDRHN--LRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLF 314
            |||.:  |||  |..|...:..|..::|..|.|.|....:|..|...|..::.|||..  |.:||
Human   318 CGKVF--RHNSYLATHRRIHTGEKPYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNE--CGKLF 378

  Fly   315 ISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFA--SY 377
            ....||:.|...|:|   .|...|..|||.|....:|..| ...|.|||||||..|.:||.  ||
Human   379 TQNSHLISHWRIHTG---EKPYKCNECGKAFSVRSSLAIH-QTIHTGEKPYKCNECGKVFRYNSY 439

  Fly   378 AEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP-----GAPIIANNKRVL 437
                   |.|||...|..:..:|..|.:.||...:|..|.......:|     .:.:...|.::.
Human   440 -------LGRHRRVHTGEKPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQLA 497

  Fly   438 QQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEK 502
            ..:|.......::|..|.:.|:::|:|..|.|:|| .::|:.|..|.|.|.:...::.|...|..
Human   498 NHRRIHTGEKPYKCNECGKAFSVRSSLTTHQAIHS-GEKPYKCIECGKSFTQKSHLRSHRGIHSG 561

  Fly   503 EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDL 567
            |||..|:.|||.||....|.:|...| ..||.:|||.||||:....||..||..|||:..|||..
Human   562 EKPYKCNECGKVFAQTSQLARHWRVH-TGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKPYKCHE 625

  Fly   568 CQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |.:.|..:..|.|| ::.|...:|:..::
Human   626 CGKVFRHNSYLATH-RRIHTGEKPYKCNE 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	96/318 (30%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	9/21 (43%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	6/18 (33%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523	5/25 (20%)
		C2H2 Zn finger	259..279	CDD:275368	4/23 (17%)
		zf-H2C2_2	271..295	CDD:290200	9/24 (38%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		zf-H2C2_2	299..324	CDD:290200	8/26 (31%)
		C2H2 Zn finger	315..335	CDD:275368	9/21 (43%)
		zf-H2C2_2	327..350	CDD:290200	6/22 (27%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		zf-H2C2_2	355..380	CDD:290200	9/26 (35%)
		COG5048	367..810	CDD:227381	100/303 (33%)
		C2H2 Zn finger	371..391	CDD:275368	7/21 (33%)
		C2H2 Zn finger	399..419	CDD:275368	7/20 (35%)
		zf-H2C2_2	411..436	CDD:290200	13/25 (52%)
		C2H2 Zn finger	427..447	CDD:275368	10/26 (38%)
		zf-H2C2_2	439..463	CDD:290200	8/30 (27%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	483..503	CDD:275368	2/19 (11%)
		zf-H2C2_2	496..519	CDD:290200	3/22 (14%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		zf-H2C2_2	523..548	CDD:290200	10/25 (40%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
		zf-H2C2_2	551..576	CDD:290200	10/24 (42%)
		C2H2 Zn finger	567..587	CDD:275368	8/19 (42%)
		C2H2 Zn finger	595..615	CDD:275368	10/19 (53%)
		zf-H2C2_2	607..632	CDD:290200	12/24 (50%)
		C2H2 Zn finger	623..643	CDD:275368	6/20 (30%)
		zf-H2C2_2	635..659	CDD:290200	5/20 (25%)
		C2H2 Zn finger	651..671	CDD:275368	0/3 (0%)
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..715	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	719..744	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		zf-H2C2_2	747..770	CDD:290200
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010