DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF616

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_848618.2	Gene:	ZNF616 / 90317	HGNCID:	28062	Length:	781	Species:	Homo sapiens

Alignment Length:	580	Identity:	152/580 - (26%)
Similarity:	223/580 - (38%)	Gaps:	123/580 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQY 166
            |:..|.|:|  ..|.|.:.|....:..||.|...|..          .:.|..|.|:........
Human   124 DQHSQGDVE--NNHIENQLTSNFESRLAELQKVQTEG----------RLYECNETEKTGNNGCLV 176

  Fly   167 DEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDA 231
            ...:.|.            :|.|..|   .:.::....|:.| ...|..|:||.|.||...|..|
Human   177 SPHIREK------------TYVCNEC---GKAFKASSSLINH-QRIHTTEKPYKCNECGKAFHRA 225

  Fly   232 ASRTVHLKSSHVE-KQHACGVCGK-----KYGDRHNLRH-----------------------HVE 267
            :..||| |..|.. |.:.|.||||     .|..||...|                       |..
Human   226 SLLTVH-KVVHTRGKSYQCDVCGKIFRKNSYFVRHQRSHTGQKPYICNECGKSFSKSSHLAVHQR 289

  Fly   268 KYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSS 332
            .:..|..::|.||.|.|..|..|..|...|..:|.|||..  |.:.|....:|..|:..|:|
Human   290 IHTGEKPYKCNLCGKSFSQRVHLRLHQTVHTGERPFKCNE--CGKTFKRSSNLTVHQVIHAG--- 349

  Fly   333 RKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYA----EKRIHMLER------ 387
            :|...|..|||.|.|...|..| .|.|.|||.|||..|.:||:..:    .:|||.:|:
Human   350 KKPYKCDVCGKAFRHRSNLVCH-RRIHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNE 413

  Fly   388 -------------HRENLTAIERSECMLCRQPFSSEPDL-----------------------IHH 416
                         |:...|..:..:|..|.:.:|....|                       ||.
Human   414 CGKVFSKRSSLAVHQRIHTGQKTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYKCNECGKVFSIHS 478

  Fly   417 MSAEHL-----QRP-----GAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVH 471
            ..|.|.     ::|     ...:.:.:.|:...:|.......::|..|.:.|:.:||..||..:|
Human   479 RLAAHQRIHTGEKPYKCNECGKVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIH 543

  Fly   472 SEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFK 536
            : .::|:.|..|.|.|.:...:..|.:.|..|||..|:.|||.::....|..||..| ..||.:|
Human   544 T-GEKPYKCKECGKVFSQCSRLTVHRRIHSGEKPYKCNECGKVYSQYSHLVGHRRVH-TGEKPYK 606

  Fly   537 CNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |:.||:|:....:|..|||.|||:..|||:.|...|...:.|:.| |..|...:|:..::
Human   607 CHECGKAFNQGSTLNRHQRIHTGEKPYKCNQCGNSFSQRVHLRLH-QTVHTGDRPYKCNE 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	102/394 (26%)
		C2H2 Zn finger	221..241	CDD:275368	9/19 (47%)
		C2H2 Zn finger	249..269	CDD:275368	10/47 (21%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	6/42 (14%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF616	NP_848618.2	KRAB	7..61	CDD:214630
		KRAB	7..46	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..129		1/4 (25%)
		C2H2 Zn finger	187..207	CDD:275368	4/23 (17%)
		zf-H2C2_2	199..224	CDD:290200	10/25 (40%)
		C2H2 Zn finger	243..263	CDD:275368	8/19 (42%)
		COG5048	266..707	CDD:227381	108/409 (26%)
		C2H2 Zn finger	271..291	CDD:275368	1/19 (5%)
		zf-H2C2_2	283..308	CDD:290200	7/24 (29%)
		C2H2 Zn finger	299..319	CDD:275368	8/19 (42%)
		zf-H2C2_2	311..336	CDD:290200	9/26 (35%)
		C2H2 Zn finger	327..347	CDD:275368	5/21 (24%)
		C2H2 Zn finger	355..375	CDD:275368	9/20 (45%)
		C2H2 Zn finger	383..403	CDD:275368	5/19 (26%)
		C2H2 Zn finger	411..431	CDD:275368	1/19 (5%)
		C2H2 Zn finger	439..459	CDD:275368	4/19 (21%)
		C2H2 Zn finger	467..487	CDD:275368	4/19 (21%)
		zf-H2C2_2	480..504	CDD:290200	3/23 (13%)
		C2H2 Zn finger	495..515	CDD:275368	2/19 (11%)
		zf-H2C2_2	508..531	CDD:290200	3/22 (14%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		zf-H2C2_2	538..560	CDD:290200	8/22 (36%)
		C2H2 Zn finger	551..571	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	591..616	CDD:290200	11/25 (44%)
		C2H2 Zn finger	607..627	CDD:275368	8/19 (42%)
		zf-H2C2_2	620..644	CDD:290200	12/23 (52%)
		C2H2 Zn finger	635..655	CDD:275368	6/20 (30%)
		zf-H2C2_2	647..672	CDD:290200	5/20 (25%)
		C2H2 Zn finger	663..683	CDD:275368	0/3 (0%)
		C2H2 Zn finger	691..711	CDD:275368
		zf-H2C2_2	703..728	CDD:290200
		C2H2 Zn finger	719..739	CDD:275368
		zf-H2C2_2	731..754	CDD:290200
		C2H2 Zn finger	747..767	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100