DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF30

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001092907.1	Gene:	ZNF30 / 90075	HGNCID:	13090	Length:	624	Species:	Homo sapiens

Alignment Length:	573	Identity:	151/573 - (26%)
Similarity:	232/573 - (40%)	Gaps:	131/573 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LEDDEIGQEDLEPAEE------HQETETTKPT------TTVSAETQPNNTASDPIEIFVDAVDID 151
            ||||.||.:::..:|.      ||:....||.      .|:..:::|           |....|.
Human    90 LEDDTIGCKEMPTSENCPSFALHQKISRQKPRECQEYGKTLCQDSKP-----------VQHERIH 143

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINAS---- 212
            .:|:....:|..:.:           |...||||........:|   |:.::.....|:.|
Human   144 SSEKPNRCKECGKNF-----------SNGHQLTIHQRLHVGEKP---YKYEKCGKAFISGSAFVK 194

  Fly   213 ----HDPEQPYNCPECEARFQDAASRTVHLKSSHV-EKQHACGVCGKKYGDRHNLRHHVEKYHSE 272
                |..|:|..|.:|......:...||| ||.|. :|.:.||.|||.:.....|..|...:..|
Human   195 HGRIHTGEKPLKCKQCGKTISGSYQLTVH-KSIHTGKKPYECGECGKAFLVYGKLTRHQSTHTGE 258

  Fly   273 TDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEH 337
            ..|.|..|.|.|.|...|..|.:.|..::.::|:.  |.:.|.:...|..|:..|:|   .|...
Human   259 KPFGCEECGKAFSTFSYLVQHQRIHTSEKPYECKE--CGKAFSTSSPLAKHQRIHTG---EKPYE 318

  Fly   338 CGFCGKTFIHLKTLRWHIYRQ-------HGGEKPYKCANCTEVFA----SYAEKRIH-------- 383
            |..|||:|.        :|.|       |.||||::|..|.:.|.    .:|.:|||
Human   319 CKECGKSFT--------VYGQLTRHQSIHTGEKPFECKECGKAFRLSSFLHAHQRIHAEIKPYGC 375

  Fly   384 -----------MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIA 431
                       .|.:|....|..:..||..|.:.||:...|:.|......::|      |...|:
Human   376 KECGRTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPYECKECGKAFIS 440

  Fly   432 NNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMK 494
            .::..:.|   |.::|  .::|..|.:.|.:...|.:|..:|::. :|:.|..|.|.|.||..:.
Human   441 RHQLTVHQ---RVHTGEKPYECKECGKAFRVHVHLTQHRKIHTDV-KPYECKECGKTFSRASYLV 501

  Fly   495 WHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYL-------------- 545
            .|.:.|..:||..|..|||||:....|.||:..| ..||.::||.||:|:.
Human   502 QHSRIHTGKKPYECKECGKAFSSGSYLVQHQRIH-TGEKPYECNKCGKAFTVYGQLIGHQSVHTG 565

  Fly   546 ---FE-----KSLRL------HQRTHTGKTYYKCDLCQERFVTHIKLKTHMQK 584
               ||     |:.||      |||.|||:..:||..|.:.|.....||.|::|
Human   566 EKPFECKECGKAFRLNSFLTEHQRVHTGEKPFKCKKCGKTFRYSSALKVHLRK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	92/356 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	7/27 (26%)
		C2H2 Zn finger	367..384	CDD:275368	7/39 (18%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	13/47 (28%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF30	NP_001092907.1	KRAB	14..75	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	<97..302	CDD:227381	52/232 (22%)
		C2H2 Zn finger	123..143	CDD:275368	3/30 (10%)
		C2H2 Zn finger	151..171	CDD:275368	6/30 (20%)
		C2H2 Zn finger	179..199	CDD:275368	2/19 (11%)
		C2H2 Zn finger	207..227	CDD:275368	7/20 (35%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		COG5048	245..624	CDD:227381	108/392 (28%)
		C2H2 Zn finger	263..283	CDD:275368	7/19 (37%)
		zf-H2C2_2	275..300	CDD:290200	6/26 (23%)
		C2H2 Zn finger	291..311	CDD:275368	5/21 (24%)
		zf-H2C2_2	304..327	CDD:290200	9/25 (36%)
		C2H2 Zn finger	319..339	CDD:275368	7/27 (26%)
		zf-H2C2_2	332..354	CDD:290200	7/21 (33%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	2/19 (11%)
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
		zf-H2C2_2	415..438	CDD:290200	4/22 (18%)
		C2H2 Zn finger	431..451	CDD:275368	4/22 (18%)
		zf-H2C2_2	444..466	CDD:290200	5/24 (21%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		zf-H2C2_2	471..496	CDD:290200	8/25 (32%)
		C2H2 Zn finger	487..507	CDD:275368	7/19 (37%)
		zf-H2C2_2	499..524	CDD:290200	10/24 (42%)
		C2H2 Zn finger	515..535	CDD:275368	9/19 (47%)
		zf-H2C2_2	527..551	CDD:290200	11/24 (46%)
		C2H2 Zn finger	543..563	CDD:275368	5/19 (26%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		zf-H2C2_2	584..608	CDD:290200	10/23 (43%)
		C2H2 Zn finger	599..619	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100