DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF587

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_116217.1	Gene:	ZNF587 / 84914	HGNCID:	30955	Length:	575	Species:	Homo sapiens

Alignment Length:	445	Identity:	113/445 - (25%)
Similarity:	190/445 - (42%)	Gaps:	87/445 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPE 216
            :.|...|:.:.:..:....:|..|:.|...: |.:::.|..:.|.     |:|...        :
Human   187 QEEAAVEKTDSETMHGPPFQEGKTNYSCGKR-TKAFSTKHSVIPH-----QKLFTR--------D 237

  Fly   217 QPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCE 281
            ..|.|.:|...|....|.:.|.:....:..:.||.|||.|..:.:|..|...:..:|.:.|..|.
Human   238 GCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSYSRKSSLIQHQRVHTGQTAYPCEECG 302

  Fly   282 KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFI 346
            |.|..:.||..|...|..:..::||.  |.:.|..:.:|:.|:..|:|   .::.|||.|||:|
Human   303 KSFSQKGSLISHQLVHTGEGPYECRE--CGKSFGQKGNLIQHQQGHTG---ERAYHCGECGKSF- 361

  Fly   347 HLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            ..|....:..|.|.||:||||..                                 |.:.|..:.
Human   362 RQKFCFINHQRVHTGERPYKCGE---------------------------------CGKSFGQKG 393

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDR 476
            :|:||......:||                       ::|..|.:.|..:|.|..|..:|: .:|
Human   394 NLVHHQRGHTGERP-----------------------YECKECGKSFRYRSHLTEHQRLHT-GER 434

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEK----EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKC 537
            |:.|..|.|.|.|    |:|:..||:    |:|..|:||||.|..|:.:|.|:..| ..|:.::|
Human   435 PYNCRECGKLFNR----KYHLLVHERVHTGERPYACEVCGKLFGNKHSVTIHQRIH-TGERPYEC 494

  Fly   538 NVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            :.||:::|...:|.:|:|.|:|:..|||..|.:.|.....|..| ::.|...:|:
Human   495 SECGKSFLSSSALHVHKRVHSGQKPYKCSECGKSFSECSSLIKH-RRIHTGERPY 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	76/313 (24%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	1/16 (6%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF587	NP_116217.1	KRAB	15..70	CDD:214630
		KRAB	15..54	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..88
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	122..142	CDD:275368
		C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	270..290	CDD:275368	8/19 (42%)
		COG5048	<273..568	CDD:227381	95/345 (28%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		C2H2 Zn finger	326..343	CDD:275368	5/18 (28%)
		C2H2 Zn finger	354..374	CDD:275368	8/20 (40%)
		zf-H2C2_2	369..389	CDD:290200	9/52 (17%)
		C2H2 Zn finger	382..402	CDD:275368	6/52 (12%)
		zf-H2C2_2	394..419	CDD:290200	8/47 (17%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		zf-H2C2_2	422..447	CDD:290200	9/25 (36%)
		C2H2 Zn finger	438..458	CDD:275368	9/23 (39%)
		zf-H2C2_2	450..473	CDD:290200	10/22 (45%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		zf-H2C2_2	478..503	CDD:290200	7/25 (28%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		zf-H2C2_2	509..530	CDD:290200	8/20 (40%)
		C2H2 Zn finger	522..542	CDD:275368	5/20 (25%)
		zf-H2C2_2	534..557	CDD:290200	4/16 (25%)
		C2H2 Zn finger	550..570	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100