DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZSCAN10

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_116194.2	Gene:	ZSCAN10 / 84891	HGNCID:	12997	Length:	780	Species:	Homo sapiens

Alignment Length:	588	Identity:	133/588 - (22%)
Similarity:	209/588 - (35%)	Gaps:	153/588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 PAEEHQETETTKPTTTVSAETQPNNTA--SDPIEIFVDAVDIDEAEEEEEE-------------- 159
            |.|..::.|.......::.|..|.|.|  :.|:.......|.:|.::||.:
Human   230 PEESSRDQELAAVLECLTFEDVPENKAWPAHPLGFGSRTPDKEEFKQEEPKGAAWPTPILAESQA 294

  Fly   160 ------------------------EEQQQQYDEEVEEPITDESAP-PQLTISYACKFC------L 193
                                    |:.......|:.|....|..| |...:.:.|..|      |
Human   295 DSPGVPGEPCAQSLGRGAAASGPGEDGSLLGSSEILEVKVAEGVPEPNPELQFICADCGVSFPQL 359

  Fly   194 RPQENYQLQ--------------------QLLLEHINASHDPEQPYNCPECEARFQDAASRTVHL 238
            ...:.:||:                    .:|..|:. :|..|:|:.|..|..||:.::..:.||
Human   360 SRLKAHQLRSHPAGRSFLCLCCGKSFGRSSILKLHMR-THTDERPHACHLCGHRFRQSSHLSKHL 423

  Fly   239 KSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSE----------------TDFECALCEKRFYTR 287
            .:...|....|..||:.:..|.:|..|:..:..:                ||..|:.|.:.|..|
Human   424 LTHSSEPAFLCAECGRGFQRRASLVQHLLAHAQDQKPPCAPESKAEAPPLTDVLCSHCGQSFQRR 488

  Fly   288 KSLNYHMKWHNPD------------------RQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            .||..|::.|..|                  |.|.|  |.|.:.|....||:.|...|:|   .:
Human   489 SSLKRHLRIHARDKDRRSSEGSGSRRRDSDRRPFVC--SDCGKAFRRSEHLVAHRRVHTG---ER 548

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLER-----HRENLTA 394
            ...|..||::|.....|..| .|.|.|||||.|..|.:.|...|....|:|..     |
Human   549 PFSCQACGRSFTQSSQLVSH-QRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPH------ 606

  Fly   395 IERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFN 459
                .|..|.:.|....||..|..:...::|                       .:|..|.:.|:
Human   607 ----HCTQCGKSFGQTQDLARHQRSHTGEKP-----------------------CRCSECGEGFS 644

  Fly   460 MKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQH 524
            ..:.|.||..:|: .::||||..|..||:.:.::..|.::|..|:|..|..||::|.....|.:|
Human   645 QSAHLARHQRIHT-GEKPHACDTCGHRFRNSSNLARHRRSHTGERPYSCQTCGRSFRRNAHLRRH 708

  Fly   525 RLSH-----EVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQK 584
            ..:|     |..|...:|..||:::....:|..|...|||...|.|..|...|..:..|..|: :
Human   709 LATHAEPGQEQAEPPQECVECGKSFSRSCNLLRHLLVHTGARPYSCTQCGRSFSRNSHLLRHL-R 772

  Fly   585 AHA 587
            .||
Human   773 THA 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	87/368 (24%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZSCAN10	NP_116194.2	SCAN	40..124	CDD:153421
		PHA03418	156..>314	CDD:177646	12/83 (14%)
		C2H2 Zn finger	349..370	CDD:275368	5/20 (25%)
		C2H2 Zn finger	378..398	CDD:275368	2/20 (10%)
		zf-H2C2_2	391..415	CDD:290200	9/24 (38%)
		COG5048	400..774	CDD:227381	105/414 (25%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-C2H2	522..544	CDD:278523	8/23 (35%)
		C2H2 Zn finger	524..544	CDD:275368	7/21 (33%)
		zf-H2C2_2	536..561	CDD:290200	9/27 (33%)
		C2H2 Zn finger	552..572	CDD:275368	7/20 (35%)
		zf-H2C2_2	565..589	CDD:290200	12/24 (50%)
		C2H2 Zn finger	580..600	CDD:275368	6/19 (32%)
		zf-H2C2_2	592..615	CDD:290200	5/32 (16%)
		C2H2 Zn finger	608..628	CDD:275368	6/19 (32%)
		zf-H2C2_2	620..645	CDD:290200	7/47 (15%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-H2C2_2	648..673	CDD:290200	11/25 (44%)
		C2H2 Zn finger	664..684	CDD:275368	5/19 (26%)
		zf-H2C2_2	676..701	CDD:290200	8/24 (33%)
		C2H2 Zn finger	692..712	CDD:275368	6/19 (32%)
		C2H2 Zn finger	728..746	CDD:275368	4/17 (24%)
		zf-H2C2_2	738..763	CDD:290200	9/24 (38%)
		zf-C2H2	752..774	CDD:278523	6/22 (27%)
		C2H2 Zn finger	754..774	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100