DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF607

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_116078.4	Gene:	ZNF607 / 84775	HGNCID:	28192	Length:	696	Species:	Homo sapiens

Alignment Length:	570	Identity:	155/570 - (27%)
Similarity:	232/570 - (40%)	Gaps:	107/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDP-IEIFVDAVDIDEAE 154
            ||.:  .||....:.:.||....|    :..:|...|..||:...|..|. .||..|.
Human    39 YDNL--VSLAGHSVSKPDLITLLE----QGKEPWMIVREETRGECTDLDSRCEIISDG------- 90

  Fly   155 EEEEEEEQQQQYDEE----VEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEH--INASH 213
                   :.|.|.:.    :.:.|.:...|      |.||.|   |:::.....|:.|  |:.|.
Human    91 -------KMQLYRKHSCVTLHQRIHNGQKP------YECKQC---QKSFSHLTELMVHQTIHTSE 139

  Fly   214 DPEQ-------------------------PYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCG 253
            :|:|                         ||.|.||...|...|:...|.| .||||.:.|..||
Human   140 EPDQCEKFRKAFSHLTDLRKHQKINAREKPYECEECGKVFSYPANLAQHGK-VHVEKPYECKECG 203

  Fly   254 KKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            :.:.....|..|...::.|..:||..|.|.|.....|:.|...|..::.|:|  :.|.:.|..:.
Human   204 EAFRTSRQLTVHHRFHYGEKPYECKECGKAFSVYGRLSRHQSIHTGEKPFEC--NKCGKSFRLKA 266

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAE---- 379
            .|..|::.|:|   .|...|..|||.|.....|..| .|.|.|||||:|..|.:.|....:
Human   267 GLKVHQSIHTG---EKPHECKECGKAFRQFSHLVGH-KRIHTGEKPYECKECGKGFTCRYQLTMH 327

  Fly   380 KRIHMLERH---REN---------LTA------IERS-ECMLCRQPFSSEPDLIHHMSAEHLQRP 425
            :||:..|:|   :||         |||      :|:. :|..|.:.||....|..|......::|
Human   328 QRIYSGEKHYECKENGEAFSSGHQLTAPHTFESVEKPYKCEECGKAFSVHGRLTRHQGIHSGKKP 392

  Fly   426 ------GAPIIANNKRVLQQK---RERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACP 481
                  |.....|:...:.|.   .|:.|    :|..|.:.|:.::.|..|..:|:.. :|..|.
Human   393 YECNKCGKSFRLNSSLKIHQNIHTGEKPY----KCKECGKAFSQRAHLAHHNRIHTGY-KPFECK 452

  Fly   482 HCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLF 546
            .|.|.|:.|..:..|.:.|..|||.||..|||.|:..:.||.||..| ..||.::|..||:|:..
Human   453 ECGKSFRCASYLVIHERIHTGEKPYVCQECGKGFSYSHKLTIHRRVH-TGEKPYECKECGKAFSV 516

  Fly   547 EKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ...|..|...|:||..::|:.|.:.|.....||.| |..|:|.:|:...:
Human   517 SGQLTQHLSIHSGKKPFECNKCGKSFRFISVLKAH-QNIHSAEKPYECKE 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	98/368 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF607	NP_116078.4	KRAB	7..67	CDD:214630	8/33 (24%)
		KRAB	7..45	CDD:279668	2/7 (29%)
		C2H2 Zn finger	116..136	CDD:275368	6/22 (27%)
		C2H2 Zn finger	144..164	CDD:275368	0/19 (0%)
		C2H2 Zn finger	172..192	CDD:275368	7/20 (35%)
		C2H2 Zn finger	199..219	CDD:275368	5/19 (26%)
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		zf-H2C2_2	240..262	CDD:290200	6/23 (26%)
		C2H2 Zn finger	255..275	CDD:275368	5/21 (24%)
		zf-H2C2_2	268..292	CDD:290200	10/26 (38%)
		COG5048	279..687	CDD:227381	89/295 (30%)
		C2H2 Zn finger	283..303	CDD:275368	8/20 (40%)
		zf-H2C2_2	295..320	CDD:290200	12/25 (48%)
		C2H2 Zn finger	311..330	CDD:275368	3/18 (17%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	3/19 (16%)
		zf-H2C2_2	407..432	CDD:290200	6/28 (21%)
		C2H2 Zn finger	423..443	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		zf-H2C2_2	463..488	CDD:290200	11/24 (46%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-H2C2_2	492..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..555	CDD:275368	7/20 (35%)
		C2H2 Zn finger	563..583	CDD:275368	0/3 (0%)
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100