DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF528

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006723481.1	Gene:	ZNF528 / 84436	HGNCID:	29384	Length:	712	Species:	Homo sapiens

Alignment Length:	451	Identity:	133/451 - (29%)
Similarity:	194/451 - (43%)	Gaps:	66/451 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 EEPITDESA-PPQLTISYACKFCL--RPQENYQLQQLLLE----HI----------------NAS 212
            |:|::|.|: .|...||.:.|..|  :.:.|:....||.:    ||                :||
Human   220 EKPVSDNSSVSPLEKISSSVKSHLLNKYRNNFDHAPLLPQEQKAHIREKAYKCNEHGQVFRASAS 284

  Fly   213 ------HDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS 271
                  |:.:.||.|.||...|..::...:|.:....||.:.|..|||.:....||..|...:..
Human   285 LTNQVIHNADNPYKCSECGKVFSCSSKLVIHRRMHTGEKPYKCHECGKLFSSNSNLSQHQRIHTG 349

  Fly   272 ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSE 336
            |..::|..|:|.|.:...|..|.:.|..::.:||..  |:::|....||:.|:..|:|   .|..
Human   350 EKPYKCHECDKVFRSSSKLAQHQRIHTGEKPYKCHE--CDKVFNQIAHLVRHQKIHTG---EKPY 409

  Fly   337 HCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECM 401
            .|..|||.|.....|..| ...|.|||||||..|.:.|:..:....|.|..     |..:..:|.
Human   410 SCNKCGKVFSRHSYLAEH-QTVHTGEKPYKCEECGKAFSVRSSLITHQLIH-----TGRKPYKCK 468

  Fly   402 LCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALER 466
            .|.:.|..:..|..|                 :|:  ..|||.|.    |..|.:.|:.||.|.|
Human   469 ECDKVFGRKCFLTSH-----------------QRI--HTRERPYG----CSQCGKIFSQKSDLIR 510

  Fly   467 HAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVL 531
            |...|:: ::|:.|..|...|:...|:..|...|..|||..|..|||.|..|..||.|...| ..
Human   511 HRKTHTD-EKPYKCNKCGTAFREFSDLTAHFLIHSGEKPYECKECGKVFRYKSSLTSHHRIH-TG 573

  Fly   532 EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            ||.:|||.||:.:....:|..||:.|||:..|||:.|.:.|.....|..| |..|...:|:
Human   574 EKPYKCNRCGKVFSRSSNLVCHQKIHTGEKPYKCNQCGKVFNQASYLTRH-QIIHTGERPY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/335 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF528	XP_006723481.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	272..291	CDD:275368	2/18 (11%)
		COG5048	277..712	CDD:227381	119/394 (30%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		zf-H2C2_2	312..336	CDD:290200	7/23 (30%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-H2C2_2	339..364	CDD:290200	8/24 (33%)
		C2H2 Zn finger	355..375	CDD:275368	6/19 (32%)
		zf-H2C2_2	368..392	CDD:290200	7/25 (28%)
		C2H2 Zn finger	383..403	CDD:275368	6/21 (29%)
		zf-H2C2_2	395..420	CDD:290200	11/27 (41%)
		C2H2 Zn finger	411..431	CDD:275368	7/20 (35%)
		zf-H2C2_2	423..447	CDD:290200	11/24 (46%)
		C2H2 Zn finger	439..459	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..487	CDD:275368	6/38 (16%)
		C2H2 Zn finger	495..515	CDD:275368	8/19 (42%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		zf-H2C2_2	535..560	CDD:290200	11/24 (46%)
		C2H2 Zn finger	551..571	CDD:275368	9/19 (47%)
		zf-H2C2_2	563..588	CDD:290200	11/25 (44%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	591..616	CDD:290200	11/24 (46%)
		C2H2 Zn finger	607..627	CDD:275368	6/20 (30%)
		zf-H2C2_2	619..642	CDD:290200	5/16 (31%)
		C2H2 Zn finger	635..655	CDD:275368
		C2H2 Zn finger	663..683	CDD:275368
		zf-H2C2_2	675..700	CDD:290200
		C2H2 Zn finger	691..711	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100