DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF611

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001154971.1	Gene:	ZNF611 / 81856	HGNCID:	28766	Length:	705	Species:	Homo sapiens

Alignment Length:	543	Identity:	145/543 - (26%)
Similarity:	232/543 - (42%)	Gaps:	84/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EIGQEDLEPAEEHQETETT------KPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEE 161
            |||.: ||.:.....:.:|      :|.|.:|     ||..::|:.     ..:...::|....|
Human   175 EIGNQ-LEKSTNDAPSVSTFQRISCRPQTQIS-----NNYGNNPLN-----SSLLPQKQEVHMRE 228

  Fly   162 QQQQYDE-----EVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNC 221
            :..|.::     .....:.....|......|.|..|   .:.:..:|.|..| :..|..|:||.|
Human   229 KSFQCNKSGKAFNCSSLLRKHQIPHLGDKQYKCDVC---GKLFNHEQYLACH-DRCHTVEKPYKC 289

  Fly   222 PECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYT 286
            .||...|...:|.|.|.:.....|::.|..|||.:|....|.........|..::|..|:|.|..
Human   290 KECGKTFSQESSLTCHRRLHTGVKRYNCNECGKIFGQNSALLIDKAIDTGENPYKCNECDKAFNQ 354

  Fly   287 RKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGT--------------------- 330
            :..|::| :.|..::.:||..  |:::|..:..:..|:..|:|.
Human   355 QSQLSHH-RIHTGEKPYKCEE--CDKVFSRKSTIETHKRIHTGEKPYRCKVCDTAFTWHSQLARH 416

  Fly   331 ----SSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHREN 391
                :::|:..|..|||||.|..:|..| :|.|||||.|||..|.:.|...::     |.:|
Human   417 RRIHTAKKTYKCNECGKTFSHKSSLVCH-HRLHGGEKSYKCKVCDKAFVWSSQ-----LAKH--- 472

  Fly   392 LTAIERSE----CMLCRQPFSSEPDLIHHMSAEHLQRP----GAPIIANNKRVLQQKR-----ER 443
             |.|:..|    |..|.:.|....||:.|.|....::|    ....:.:.|..|:..:     |:
Human   473 -TRIDCGEKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKCDECEKVFSRKSSLETHKIGHTGEK 536

  Fly   444 QYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVC 508
            .|    :|..|.:.|...|.|.:|..:|| .::|:.|..|||.|.....:..|.:.|..|||..|
Human   537 PY----KCKVCDKAFACHSYLAKHTRIHS-GEKPYKCNECSKTFSHRSYLVCHHRVHSGEKPYKC 596

  Fly   509 DVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFV 573
            :.|.|.|:.:..|..||..|.. ||.:|||.||..:....||..|:|.|||:..|||.:|.:.||
Human   597 NECSKTFSRRSSLHCHRRLHSG-EKPYKCNECGNTFRHCSSLIYHRRLHTGEKSYKCTICDKAFV 660

  Fly   574 THIKLKTHMQKAHAASQPHSADQ 596
            .:..|..| .:.|.|.:|:..::
Human   661 RNSLLSRH-TRIHTAEKPYKCNE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	93/347 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	4/21 (19%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF611	NP_001154971.1	KRAB	24..60	CDD:279668
		KRAB	24..>60	CDD:214630
		C2H2 Zn finger	233..253	CDD:275368	0/19 (0%)
		COG5048	256..698	CDD:227381	129/451 (29%)
		C2H2 Zn finger	261..281	CDD:275368	5/23 (22%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..364	CDD:275368	6/19 (32%)
		zf-H2C2_2	359..381	CDD:290200	6/24 (25%)
		C2H2 Zn finger	372..392	CDD:275368	4/21 (19%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	428..448	CDD:275368	10/20 (50%)
		C2H2 Zn finger	456..475	CDD:275368	6/27 (22%)
		C2H2 Zn finger	484..504	CDD:275368	7/19 (37%)
		C2H2 Zn finger	512..532	CDD:275368	2/19 (11%)
		zf-H2C2_2	524..549	CDD:290200	6/28 (21%)
		C2H2 Zn finger	540..560	CDD:275368	6/19 (32%)
		zf-H2C2_2	552..577	CDD:290200	10/25 (40%)
		C2H2 Zn finger	568..588	CDD:275368	6/19 (32%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368	8/19 (42%)
		C2H2 Zn finger	652..672	CDD:275368	6/20 (30%)
		zf-H2C2_2	665..689	CDD:290200	5/19 (26%)
		C2H2 Zn finger	680..700	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100