DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF34

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_085057.3	Gene:	ZNF34 / 80778	HGNCID:	13098	Length:	560	Species:	Homo sapiens

Alignment Length:	477	Identity:	128/477 - (26%)
Similarity:	196/477 - (41%)	Gaps:	89/477 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EAEEEEEEEEQQQQYDEEVE------------EPITDESAPPQLTISYACKFCLRPQENYQLQQL 204
            |...:|...|:..|..|.||            |.:.::..|..:|::..    ...:|:....:|
Human   124 ELTSQETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNG----ESSRESGGNLRL 184

  Fly   205 LLEHINASHDPEQ-PYNCPECEARFQDAA----SRTVH--LKSSHV------------------- 243
            |...:     |:| |:.|..||..|:..:    .:.||  .|::.|
Human   185 LSRPV-----PDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVKEDQKI 244

  Fly   244 ---EKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKC 305
               :|.|.|..|||.:....||..|...:..|..::|..|.|.|........|.:.|:.:..::|
Human   245 PTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPYKCDECGKAFSQSCEFINHRRMHSGEIPYRC 309

  Fly   306 RHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANC 370
              ..|.:.|..:.:||.|:..|:|   .|...||.|||.|....:|.:| .|.|.|||||||.:|
Human   310 --DECGKTFTRRPNLMKHQRIHTG---EKPYKCGECGKHFSAYSSLIYH-QRIHTGEKPYKCNDC 368

  Fly   371 TEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKR 435
            .:.|:..:     :|.|||...|..:..||..|.:.|:...:||.|......::|
Human   369 GKAFSDGS-----ILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIHTGEKP---------- 418

  Fly   436 VLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTH 500
                         ::|..|.:.|..|:.|..|...|: .::|:.|..|.|.|.::..:..|.:.|
Human   419 -------------YKCNECEKAFIQKTKLVEHQRSHT-GEKPYECNDCGKVFSQSTHLIQHQRIH 469

  Fly   501 EKEKPNVCDVCGKAFALKYVLTQH-RLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYK 564
            ..|||..|..|||||.....|..| ||.|.  ||.::|:.|.:|:.....|..|:|.|||:..||
Human   470 TGEKPYKCSECGKAFHNSSRLIHHQRLHHG--EKPYRCSDCKKAFSQSTYLIQHRRIHTGEKPYK 532

  Fly   565 CDLCQERFVTHIKLKTHMQKAH 586
            |..|.:.| .|.......|:.|
Human   533 CSECGKAF-RHSSNMCQHQRIH 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	87/338 (26%)
		C2H2 Zn finger	221..241	CDD:275368	7/25 (28%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/20 (50%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF34	NP_085057.3	KRAB	35..97	CDD:214630
		KRAB	35..74	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..188		5/28 (18%)
		COG5048	188..554	CDD:227381	115/409 (28%)
		C2H2 Zn finger	197..217	CDD:275368	4/19 (21%)
		zf-C2H2	251..273	CDD:278523	8/21 (38%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	265..290	CDD:290200	8/24 (33%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		zf-C2H2	307..329	CDD:278523	6/23 (26%)
		C2H2 Zn finger	309..329	CDD:275368	6/21 (29%)
		zf-H2C2_2	321..345	CDD:290200	11/26 (42%)
		C2H2 Zn finger	337..357	CDD:275368	9/20 (45%)
		zf-H2C2_2	349..373	CDD:290200	12/24 (50%)
		C2H2 Zn finger	365..385	CDD:275368	7/24 (29%)
		zf-H2C2_2	378..402	CDD:290200	9/23 (39%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		zf-H2C2_2	405..430	CDD:290200	7/47 (15%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..458	CDD:290200	8/24 (33%)
		C2H2 Zn finger	449..469	CDD:275368	5/19 (26%)
		zf-H2C2_2	461..486	CDD:290200	11/24 (46%)
		C2H2 Zn finger	477..497	CDD:275368	9/19 (47%)
		zf-H2C2_2	493..514	CDD:290200	9/22 (41%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		zf-H2C2_2	517..542	CDD:290200	11/25 (44%)
		C2H2 Zn finger	533..553	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100