DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF552

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_079038.2	Gene:	ZNF552 / 79818	HGNCID:	26135	Length:	407	Species:	Homo sapiens

Alignment Length:	413	Identity:	102/413 - (24%)
Similarity:	162/413 - (39%)	Gaps:	69/413 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 ITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHL 238
            :.||:||.:.:|             |..::..:....|...|::.:.|..|.....|......|.
Human    59 VEDEAAPSKQSI-------------YIQRETQVRTPMAGVSPKKAHPCEMCGPILGDILHVADHQ 110

  Fly   239 KSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQF 303
            .:.|.:|.|.|...|.|..|..|...|..::..|..:..::.|..|..|      .|.|......
Human   111 GTHHKQKLHRCEAWGNKLYDSGNFHQHQNEHIGEKPYRGSVEEALFAKR------CKLHVSGESS 169

  Fly   304 KCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCA 368
            ....||.:  |:.:..|:..||||:|.|:.|:|    |...|             |||:..|.|.
Human   170 VFSESGKD--FLLRSGLLQQEATHTGKSNSKTE----CVSLF-------------HGGKSHYSCG 215

  Fly   369 NCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANN 433
            .|.:.|::.     .:|.:|...|...|.|....|.:..|......:|......::|
Human   216 GCMKHFSTK-----DILSQHERLLPTEEPSVWCECGKSSSKYDSFSNHQGVHTREKP-------- 267

  Fly   434 KRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIK 498
                           :.||.|.:.||.||.|..|..:|: .::|:.|..|.|.|:....:..|.:
Human   268 ---------------YTCGICGKLFNSKSHLLVHQRIHT-GEKPYECEVCQKFFRHKYHLIAHQR 316

  Fly   499 THEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYY 563
            .|..|:|..|..|||:|........|:..| ..:|.::|:.||:::....||..|:|.|||:..|
Human   317 VHTGERPYECSDCGKSFTHSSTFRVHKRVH-TGQKPYECSECGKSFAESSSLTKHRRVHTGEKPY 380

  Fly   564 KCDLCQERFVTHIKLKTHMQKAH 586
            .|..|:::| ..|....|.|:.|
Human   381 GCSECEKKF-RQISSLRHHQRVH 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	71/309 (23%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	2/20 (10%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF552	NP_079038.2	KRAB	14..>55	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	93..113	CDD:275368	4/19 (21%)
		C2H2 Zn finger	121..141	CDD:275368	6/19 (32%)
		C2H2 Zn finger	214..234	CDD:275368	5/24 (21%)
		COG5048	<243..407	CDD:227381	49/186 (26%)
		C2H2 Zn finger	244..262	CDD:275368	3/17 (18%)
		C2H2 Zn finger	270..290	CDD:275368	9/19 (47%)
		zf-H2C2_2	282..307	CDD:290200	8/25 (32%)
		C2H2 Zn finger	298..318	CDD:275368	5/19 (26%)
		zf-H2C2_2	310..335	CDD:290200	9/24 (38%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..362	CDD:290200	6/23 (26%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		C2H2 Zn finger	382..402	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100