DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF665

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	477	Identity:	139/477 - (29%)
Similarity:	206/477 - (43%)	Gaps:	65/477 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 EEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPEC 224
            |.||.|::.::.|....|.:|......|.|..|   .:.:.....|..| ...|..|:||.|.:|
Human   179 ELQQFQHEGKIYEYNQVEKSPNNRGKHYKCDEC---GKVFSQNSRLTSH-KRIHTGEKPYQCNKC 239

  Fly   225 EARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKS 289
            ...|...::.|:|......||.:.|..|||.:....||..|...:..|..::|..|.|.|.....
Human   240 GKAFTVRSNLTIHQVIHTGEKPYKCNECGKVFSQPSNLAGHQRIHTGEKPYKCNECGKAFRAHSK 304

  Fly   290 LNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWH 354
            |..|...|..::.:||:.  |.:.|....||..|...|:|   .|...|..|||.|....:|..|
Human   305 LTTHQVIHTGEKPYKCKE--CGKCFTQNSHLASHRRIHTG---EKPYKCNECGKAFSVRSSLTTH 364

  Fly   355 IYRQHGGEKPYKCANCTEVFA--SYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHM 417
             ...|.|||||||..|.:||.  ||       |.:||...|..:..:|..|.:.||...:|..|.
Human   365 -QTIHTGEKPYKCNECGKVFRHNSY-------LAKHRRIHTGEKPYKCNECGKAFSMHSNLTKHQ 421

  Fly   418 SAEHLQRP-----------GAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVH 471
            .....::|           ....:||::|:  ...|:.|    :|..|.:.|:::|:|..|.|:|
Human   422 IIHTGEKPFKCNECVKVFTQYSHLANHRRI--HTGEKPY----RCDECGKAFSVRSSLTTHQAIH 480

  Fly   472 S-EK--------------------------DRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCD 509
            : ||                          ::|:.|..|.|.|.:...:..|.:.|..|||..|:
Human   481 TGEKPYKCNDCGKVFTQNSHLASHRGIHSGEKPYKCDECGKAFSQTSQLARHWRVHTGEKPYKCN 545

  Fly   510 VCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVT 574
            .|||||::...||.|:..| ..:|.:|||.||:.:.....|.:|||.|||:..|||:.|.:.|..
Human   546 ECGKAFSVHSSLTIHQTIH-TGQKPYKCNDCGKVFRHNSYLAIHQRIHTGEKPYKCNECGKAFSV 609

  Fly   575 HIKLKTHMQKAHAASQPHSADQ 596
            |..|.|| |..|...:|:..::
Human   610 HSNLATH-QVIHTGEKPYKCNE 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	94/349 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	6/18 (33%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	115/411 (28%)
		C2H2 Zn finger	208..228	CDD:275368	4/23 (17%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	6/21 (29%)
		C2H2 Zn finger	348..368	CDD:275368	7/20 (35%)
		C2H2 Zn finger	376..396	CDD:275368	9/26 (35%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		C2H2 Zn finger	432..452	CDD:275368	3/21 (14%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	0/19 (0%)
		C2H2 Zn finger	516..536	CDD:275368	5/19 (26%)
		C2H2 Zn finger	544..564	CDD:275368	9/19 (47%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	584..608	CDD:316026	11/23 (48%)
		C2H2 Zn finger	600..620	CDD:275368	8/20 (40%)
		zf-H2C2_2	612..637	CDD:316026	6/20 (30%)
		C2H2 Zn finger	628..648	CDD:275368	0/3 (0%)
		zf-H2C2_2	640..664	CDD:316026
		C2H2 Zn finger	656..676	CDD:275368
		zf-H2C2_2	669..693	CDD:316026
		C2H2 Zn finger	684..704	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010