DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF419

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001091961.1	Gene:	ZNF419 / 79744	HGNCID:	20648	Length:	511	Species:	Homo sapiens

Alignment Length:	454	Identity:	126/454 - (27%)
Similarity:	195/454 - (42%)	Gaps:	82/454 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 AEEEEEEEE-----------QQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQL-- 204
            ||.||..|:           ||.|.....|:|:..:..  ::.:..:||..| .:::.|.:::
Human   106 AEAEEAPEQIASVGLLSSNIQQHQKQHCGEKPLKRQEG--RVPVLRSCKVHL-SEKSLQSREVGK 167

  Fly   205 -------LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQH-ACGVCGKKYGDRHN 261
                   :|:| ..:|..|:.:...:....|             |..|:| .|..|||.:|.::.
Human   168 ALLISSGVLKH-QVTHTGEKSHRSSKSREAF-------------HAGKRHYKCSECGKAFGQKYL 218

  Fly   262 LRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEAT 326
            |..|...:..:..:||:.|.|.|....:|..|...|..:|.:.|  |.|.:.|....||:.|:..
Human   219 LVQHQRLHAGKKTYECSECGKLFRDMSNLFIHQIVHTGERPYGC--SNCGKSFSRNAHLIEHQRV 281

  Fly   327 HSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYA----EKRIHMLER 387
            |:|   .|...|..|||.|.|..||..| ::.|.|.:||:|:.|.::|:..:    .:|||..||
Human   282 HTG---EKPFTCSECGKAFRHNSTLVQH-HKIHTGVRPYECSECGKLFSFNSSLMKHQRIHTGER 342

  Fly   388 HRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCG 452
                     ..:|..|.:.:|.:.:||.|......:||                       ::|.
Human   343 ---------PYKCSECGKFYSHKSNLIKHWRVHTGERP-----------------------YKCS 375

  Fly   453 SCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFAL 517
            .|.:.|...|:|.:|..||: .::|..|..|.:.|:....:..|.:.|...||..|..|||.|:.
Human   376 DCGKFFTQCSSLMQHQKVHT-GEKPFKCNECGRFFRENSTLVRHQRVHTGAKPYECRECGKFFSQ 439

  Fly   518 KYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ...|.|||..| :.||.||||.|||.:....||..|||.|||...|:|..|.:.|..:..|..|
Human   440 SSTLMQHRKVH-IGEKPFKCNECGRLFRENSSLVKHQRVHTGAKPYECRECGKFFRHNSSLFKH 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	80/323 (25%)
		C2H2 Zn finger	221..241	CDD:275368	1/19 (5%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	5/17 (29%)
ZNF419	NP_001091961.1	KRAB	28..88	CDD:214630
		KRAB	28..67	CDD:279668
		C2H2 Zn finger	151..182	CDD:275368	6/32 (19%)
		C2H2 Zn finger	206..226	CDD:275368	7/19 (37%)
		C2H2 Zn finger	234..254	CDD:275368	6/19 (32%)
		COG5048	<262..418	CDD:227381	51/194 (26%)
		C2H2 Zn finger	262..282	CDD:275368	7/21 (33%)
		zf-H2C2_2	274..299	CDD:290200	11/27 (41%)
		C2H2 Zn finger	290..310	CDD:275368	9/20 (45%)
		C2H2 Zn finger	318..338	CDD:275368	4/19 (21%)
		zf-H2C2_2	330..355	CDD:290200	7/33 (21%)
		C2H2 Zn finger	346..366	CDD:275368	6/19 (32%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		zf-H2C2_2	386..409	CDD:290200	7/23 (30%)
		C2H2 Zn finger	402..422	CDD:275368	4/19 (21%)
		zf-H2C2_2	415..439	CDD:290200	9/23 (39%)
		C2H2 Zn finger	430..450	CDD:275368	9/19 (47%)
		zf-H2C2_2	443..465	CDD:290200	14/22 (64%)
		C2H2 Zn finger	458..478	CDD:275368	10/19 (53%)
		zf-H2C2_2	470..495	CDD:290200	12/24 (50%)
		C2H2 Zn finger	486..506	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100