DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp623

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_084475.1	Gene:	Zfp623 / 78834	MGIID:	1926084	Length:	499	Species:	Mus musculus

Alignment Length:	518	Identity:	135/518 - (26%)
Similarity:	208/518 - (40%)	Gaps:	100/518 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 SDPIEIFVDAVDIDEAEEEEEEEEQQQQY-----DEEVEEPITDESAPPQLTISY-------ACK 190
            ||.:.:    ::...:|..|..|::..|.     .:.:|.|.:.:....|:|:::       ..:
Mouse     3 SDELTV----LEPSASESREFHEDRLAQLLGNPDKQSLESPSSQDGGFTQMTVTHWKIQTGDTAQ 63

  Fly   191 FCLRPQENYQLQQLLL----EHINA-----------------------SHDPEQPYNCPECEARF 228
            .|.:...|..|...||    |.|:|                       ||..|:||.|..|...|
Mouse    64 TCSKSGRNPILNSNLLILQRELIDAEARSCGGGGKGFPFNSDVVPHQISHTGEKPYKCDHCGKGF 128

  Fly   229 QDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYH 293
            ...:..|.|.:....::...|.||||.:....:||.|...:..|..|:||.|.|.|.....|..|
Mouse   129 SQTSLLTEHQRVHTGDRLCVCHVCGKDFVHYASLREHQHVHTGEKPFKCAQCGKAFCHSSDLLRH 193

  Fly   294 MKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQ 358
            .:.|..:|.|:|:.  |.:.|.....|:.|:..|:|   .:...|..|||:||...:|..| |:.
Mouse   194 QRVHTRERPFECKE--CGKGFSQSSLLIRHQRIHTG---ERPYECNECGKSFIRSSSLIRH-YQI 252

  Fly   359 HGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIER-------SECMLCRQPFSSEPDLIHH 416
            |...|.|:|.:|.:.|            |||.:|...:|       .||..|.:.|.....||.|
Mouse   253 HTEVKQYECRDCGKAF------------RHRSDLIEHQRIHTGERPFECQECGKAFIRSSKLIQH 305

  Fly   417 MSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACP 481
            ......:||                       :.|..|.:||:..|...:|..:|| .::.:.|.
Mouse   306 QRIHTGERP-----------------------YVCNECGKRFSQTSNFTQHQRIHS-GEKLYECN 346

  Fly   482 HCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLF 546
            .|.|.|..:..:..|.|.|..|:...|..|||||..|..||:|:..| ..::.|:|..||:|::.
Mouse   347 ECGKAFFLSSYLIRHQKIHTGERVYECKECGKAFLQKAHLTEHQKIH-TGDRPFECKDCGKAFIQ 410

  Fly   547 EKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ------PLDDLIN 603
            ...|.|||..|||:..|.|..|.:.|:.......| ||.|...:.::..|      |..||::
Mouse   411 SSKLLLHQIVHTGEKPYVCSYCGKGFIQRSNFLQH-QKMHTEEKRYTYSQLGKDLTPPPDLVH 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/343 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp623	NP_084475.1	C2H2 Zn finger	93..113	CDD:275370	0/19 (0%)
		zf-H2C2_2	109..130	CDD:372612	8/20 (40%)
		C2H2 Zn finger	121..141	CDD:275368	5/19 (26%)
		C2H2 Zn finger	149..169	CDD:275368	8/19 (42%)
		COG5048	<173..322	CDD:227381	49/189 (26%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		C2H2 Zn finger	205..225	CDD:275368	5/21 (24%)
		C2H2 Zn finger	233..253	CDD:275368	9/20 (45%)
		C2H2 Zn finger	261..281	CDD:275368	8/31 (26%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		zf-C2H2	315..337	CDD:333835	6/21 (29%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		zf-H2C2_2	357..382	CDD:372612	10/24 (42%)
		C2H2 Zn finger	373..393	CDD:275368	10/19 (53%)
		zf-H2C2_2	385..410	CDD:372612	9/25 (36%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		C2H2 Zn finger	429..449	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100