DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF227

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001276095.1	Gene:	ZNF227 / 7770	HGNCID:	13020	Length:	799	Species:	Homo sapiens

Alignment Length:	421	Identity:	131/421 - (31%)
Similarity:	195/421 - (46%)	Gaps:	33/421 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACG 250
            ||.|..|   .:.:.....|:.|.. :|..|:||.|.||...|..:::...|.:....||.:.|.
Human   323 SYRCDSC---GKGFSSSTGLIIHYR-THTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCE 383

  Fly   251 VCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFI 315
            .|||.:|...|||.|...:..|..::|..|.|.|......:.|.:.|..::.:||  ..|.:.|.
Human   384 ECGKGFGWSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKC--DVCGKGFS 446

  Fly   316 SQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEK 380
            ....|:||...|:|   .|...|..|||.|.....|..| :|.|.|||||||..|.:.|:..:..
Human   447 HNSPLICHRRVHTG---EKPYKCEACGKGFTRNTDLHIH-FRVHTGEKPYKCKECGKGFSQASNL 507

  Fly   381 RIHMLERHRENL-TAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQ 438
            ::|      :|: |..:|.:|..|.:.||....|..|......::|      |.....::...|.
Human   508 QVH------QNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLH 566

  Fly   439 Q---KRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTH 500
            |   ..|:.|    :|..|.:.|:.:|.|..|..||| .::|:.|..|.|.|.:|.|.:.|.:.|
Human   567 QVIHTGEKPY----KCEECGKGFSWRSNLHAHQRVHS-GEKPYKCEQCDKSFSQAIDFRVHQRVH 626

  Fly   501 EKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKC 565
            ..|||..|.||||.|:....|..|:..| ..||.:||:|||:.:.:......|||.|||:..|||
Human   627 TGEKPYKCGVCGKGFSQSSGLQSHQRVH-TGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKC 690

  Fly   566 DLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            :.|.:.|...:.|: |.|:.|...:||..::
Human   691 EECGKGFGRSLNLR-HHQRVHTGEKPHICEE 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	94/319 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	9/19 (47%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF227	NP_001276095.1	KRAB	23..83	CDD:214630
		C2H2 Zn finger	326..346	CDD:275368	4/23 (17%)
		zf-H2C2_2	342..363	CDD:316026	9/21 (43%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		C2H2 Zn finger	382..402	CDD:275368	9/19 (47%)
		COG5048	406..779	CDD:227381	104/334 (31%)
		C2H2 Zn finger	410..430	CDD:275368	5/19 (26%)
		C2H2 Zn finger	438..458	CDD:275368	6/21 (29%)
		C2H2 Zn finger	466..486	CDD:275368	8/20 (40%)
		C2H2 Zn finger	494..514	CDD:275368	5/25 (20%)
		C2H2 Zn finger	522..542	CDD:275368	6/19 (32%)
		C2H2 Zn finger	550..570	CDD:275368	3/19 (16%)
		C2H2 Zn finger	578..598	CDD:275368	6/19 (32%)
		C2H2 Zn finger	606..626	CDD:275368	7/19 (37%)
		C2H2 Zn finger	634..654	CDD:275368	8/19 (42%)
		C2H2 Zn finger	662..682	CDD:275368	7/19 (37%)
		C2H2 Zn finger	690..710	CDD:275368	6/20 (30%)
		C2H2 Zn finger	718..738	CDD:275368	0/3 (0%)
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910