DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF226

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001027544.1	Gene:	ZNF226 / 7769	HGNCID:	13019	Length:	803	Species:	Homo sapiens

Alignment Length:	574	Identity:	149/574 - (25%)
Similarity:	222/574 - (38%)	Gaps:	129/574 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NLKISPND-------GLPQKICSDCFTKFCSINAF-----------RLACQEAQLKLSH-----I 90
            |:||...|       |.....|::|...|..:::|           .|.|.|......:     :
Human   233 NMKILTFDHNSMIHTGQKSYQCNECKKPFSDLSSFDLHQQLQSGEKSLTCVERGKGFCYSPVLPV 297

  Fly    91 YDKID-ASSLEDDEIGQEDLEPA--EEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDE 152
            :.|:. ...|:.||.|:|..:.|  :.||:...
Human   298 HQKVHVGEKLKCDECGKEFSQGAHLQTHQKVHV-------------------------------- 330

  Fly   153 AEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQ 217
                             :|:|             |.||.|   .:.:..:..|..|... |..|:
Human   331 -----------------IEKP-------------YKCKQC---GKGFSRRSALNVHCKV-HTAEK 361

  Fly   218 PYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEK 282
            ||||.||...|..|:....|.:....||...|..|||.:....:|:.|...:..|..::|..|.|
Human   362 PYNCEECGRAFSQASHLQDHQRLHTGEKPFKCDACGKSFSRNSHLQSHQRVHTGEKPYKCEECGK 426

  Fly   283 RFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIH 347
            .|....:|..|.:.|..::.:||..  |.:.|.....|..|:..|:|   .||..|..|||.|..
Human   427 GFICSSNLYIHQRVHTGEKPYKCEE--CGKGFSRPSSLQAHQGVHTG---EKSYICTVCGKGFTL 486

  Fly   348 LKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPD 412
            ...|:.| .|.|.|||||||..|.:.|...:..::|::..     |..:..:|.:|.:.||....
Human   487 SSNLQAH-QRVHTGEKPYKCNECGKSFRRNSHYQVHLVVH-----TGEKPYKCEICGKGFSQSSY 545

  Fly   413 LIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRP 477
            |..|..|..:::|                       |:|..|.|.||..|.|:.|..:|: .::|
Human   546 LQIHQKAHSIEKP-----------------------FKCEECGQGFNQSSRLQIHQLIHT-GEKP 586

  Fly   478 HACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGR 542
            :.|..|.|.|.|..|:|.|.:.|..|||..|:.|||.|.....|..|:..|.. ||.|||..||:
Human   587 YKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFRQASNLLAHQRVHSG-EKPFKCEECGK 650

  Fly   543 AYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ::.....|:.||:.|||...||||.|.:.|...:.|..| |:.|...:|:...:
Human   651 SFGRSAHLQAHQKVHTGDKPYKCDECGKGFKWSLNLDMH-QRVHTGEKPYKCGE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	12/55 (22%)
		COG5048	198..>508	CDD:227381	90/309 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF226	NP_001027544.1	KRAB	8..67	CDD:214630
		C2H2 Zn finger	256..302	CDD:275370	7/45 (16%)
		SUF4-like	306..>357	CDD:411020	16/116 (14%)
		C2H2 Zn finger	309..334	CDD:411020	8/73 (11%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:411020	5/23 (22%)
		C2H2 Zn finger	337..357	CDD:275368	5/23 (22%)
		COG5048	359..774	CDD:227381	119/382 (31%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..469	CDD:275368	5/21 (24%)
		C2H2 Zn finger	477..497	CDD:275368	8/20 (40%)
		C2H2 Zn finger	505..525	CDD:275368	4/19 (21%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368	8/19 (42%)
		C2H2 Zn finger	617..637	CDD:275368	7/19 (37%)
		C2H2 Zn finger	645..665	CDD:275368	6/19 (32%)
		C2H2 Zn finger	673..693	CDD:275368	7/20 (35%)
		C2H2 Zn finger	701..721	CDD:275368	0/3 (0%)
		C2H2 Zn finger	729..749	CDD:275368
		C2H2 Zn finger	757..777	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..803
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910