DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF224

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001308574.1	Gene:	ZNF224 / 7767	HGNCID:	13017	Length:	707	Species:	Homo sapiens

Alignment Length:	632	Identity:	161/632 - (25%)
Similarity:	228/632 - (36%)	Gaps:	180/632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FVCDFENG--------------------SNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPND 56
            |.|..|.|                    |:.||| |.|.         |:             :.
Human   130 FPCQTEAGLSVIHTRQKSSQGNGYKPSFSDVSHF-DFHQ---------QL-------------HS 171

  Fly    57 GLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPA--EEHQETE 119
            |.....|.:|...||.|:|.|:.      :..|:.:|    ..:.|..|:|..:.:  :.||...
Human   172 GEKSHTCDECGKNFCYISALRIH------QRVHMGEK----CYKCDVCGKEFSQSSHLQTHQRVH 226

  Fly   120 TTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLT 184
            |.                                                 |:|..
Human   227 TG-------------------------------------------------EKPFK--------- 233

  Fly   185 ISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHAC 249
                   |:...:.:..:..|..| :..|..|:||||.||...|...:....|.:....||...|
Human   234 -------CVECGKGFSRRSALNVH-HKLHTGEKPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKC 290

  Fly   250 GVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLF 314
            .:|||.:..|..|..|...:.:|..|.|..|:|.|..|.:||.|...|..::.:||..  |.:.|
Human   291 DICGKSFCGRSRLNRHSMVHTAEKPFRCDTCDKSFRQRSALNSHRMIHTGEKPYKCEE--CGKGF 353

  Fly   315 ISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFAS--- 376
            |.:|.|..|...|:|   .|..:|..|||:|.....|..| .|.|.||||:||..|.:.|.:
Human   354 ICRRDLYTHHMVHTG---EKPYNCKECGKSFRWASCLLKH-QRVHSGEKPFKCEECGKGFYTNSQ 414

  Fly   377 -YAEKRIHM-------------------LERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEH 421
             |:.:|.|.                   |:.|:...|..:...|..|.:.||..|.|:.|
Human   415 CYSHQRSHSGEKPYKCVECGKGYKRRLDLDFHQRVHTGEKLYNCKECGKSFSRAPCLLKH----- 474

  Fly   422 LQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCS 484
                                ||.:||  .|||..|.:||...|.|..|..||: .::|:.|..|.
Human   475 --------------------ERLHSGEKPFQCEECGKRFTQNSHLHSHQRVHT-GEKPYKCEKCG 518

  Fly   485 KRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKS 549
            |.:....::..|.|.|..|:|..|..|||:|.....|.:|:..|.. ||.|||..||:.:.....
Human   519 KGYNSKFNLDMHQKVHTGERPYNCKECGKSFGWASCLLKHQRLHSG-EKPFKCEECGKRFTQNSQ 582

  Fly   550 LRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |..|||.|||:..||||.|.:.|.......|| |:.|:...|...:|
Human   583 LHSHQRVHTGEKPYKCDECGKGFSWSSTRLTH-QRRHSRETPLKCEQ 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	19/94 (20%)
		COG5048	198..>508	CDD:227381	97/334 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF224	NP_001308574.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	178..198	CDD:275368	7/25 (28%)
		COG5048	202..641	CDD:227381	141/531 (27%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		zf-H2C2_2	218..243	CDD:290200	6/89 (7%)
		C2H2 Zn finger	234..254	CDD:275368	3/20 (15%)
		C2H2 Zn finger	262..282	CDD:275368	5/19 (26%)
		zf-H2C2_2	275..297	CDD:290200	7/21 (33%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368	7/21 (33%)
		C2H2 Zn finger	374..394	CDD:275368	8/20 (40%)
		C2H2 Zn finger	402..422	CDD:275368	5/19 (26%)
		C2H2 Zn finger	430..450	CDD:275368	2/19 (11%)
		C2H2 Zn finger	458..478	CDD:275368	9/44 (20%)
		zf-H2C2_2	471..495	CDD:290200	12/48 (25%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		C2H2 Zn finger	514..534	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..549	CDD:290200	9/22 (41%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..579	CDD:290200	10/24 (42%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..606	CDD:290200	11/20 (55%)
		C2H2 Zn finger	598..618	CDD:275368	7/20 (35%)
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000