DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF189

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_003443.2	Gene:	ZNF189 / 7743	HGNCID:	12980	Length:	626	Species:	Homo sapiens

Alignment Length:	552	Identity:	147/552 - (26%)
Similarity:	225/552 - (40%)	Gaps:	108/552 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 DKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPI--EIFVDAVDIDEAE 154
            |.::....|:..:.|| :|..||..|.:....|...|...|      ||:  |.|.....:|:..
Human    54 DVLNRDKDEEPTVKQE-IEEIEEEVEPQGVIVTRIKSEIDQ------DPMGRETFELVGRLDKQR 111

  Fly   155 -------EEEEEEEQQQQYDEEV----EEPITDESAPPQLTISYACKFC----LRPQENYQLQQL 204
                   ..|...::|:.:.|..    :.|.::|..       :.|:.|    :|.....|.|::
Human   112 GIFLWEIPRESLTQEQRMFRENTNIIRKRPNSEEKC-------HKCEECGKGFVRKAHFIQHQRV 169

  Fly   205 LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKY 269
                    |..|:|:.|.||...|..::....|.:....|:.:.|..|||.:.....|..|...:
Human   170 --------HTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIH 226

  Fly   270 HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            ..|..::|..|::.|..|:||..|.:.|..::..||  |.|.:.|..:.||:.|:.||:|   .|
Human   227 TGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKC--SDCGKAFSWKSHLIEHQRTHTG---EK 286

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVF--ASYAEKRIHMLERHRENLTAIER 397
            ..||..|.|:|.....|..| .|.|.||:|:||..|.:.|  ::|       |.:|::..|..:.
Human   287 PYHCTKCKKSFSRNSLLVEH-QRIHTGERPHKCGECGKAFRLSTY-------LIQHQKIHTGEKP 343

  Fly   398 SECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKS 462
            ..|:.|.:.||....||.|......:||                       :||..|.:.|:...
Human   344 FLCIECGKSFSRSSFLIEHQRIHTGERP-----------------------YQCKECGKSFSQLC 385

  Fly   463 ALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEK------------PNV-------- 507
            .|.||..:|: .|:||.|..|.|.|.|:..:..|.:.|.:||            ||.
Human   386 NLTRHQRIHT-GDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEV 449

  Fly   508 --------CDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYK 564
                    ||.|||.|::...|.||:..| ..||.:.|.|||:::.....|..|||.|||:..|.
Human   450 YPKEKSYKCDECGKTFSVSAHLVQHQRIH-TGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYL 513

  Fly   565 CDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |..|.:.|.....|..| |..|..::||..|:
Human   514 CRQCGKSFSQLCNLIRH-QGVHTGNKPHKCDE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/339 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/18 (22%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF189	NP_003443.2	KRAB	13..54	CDD:396083	147/552 (27%)
		COG5048	138..524	CDD:227381	121/438 (28%)
		C2H2 Zn finger	150..170	CDD:275368	5/27 (19%)
		C2H2 Zn finger	178..198	CDD:275368	5/19 (26%)
		C2H2 Zn finger	206..226	CDD:275368	6/19 (32%)
		C2H2 Zn finger	234..254	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	7/21 (33%)
		C2H2 Zn finger	290..310	CDD:275368	7/20 (35%)
		C2H2 Zn finger	318..338	CDD:275368	6/26 (23%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		C2H2 Zn finger	402..422	CDD:275368	6/19 (32%)
		C2H2 Zn finger	458..478	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..506	CDD:275368	8/19 (42%)
		C2H2 Zn finger	514..534	CDD:275368	6/20 (30%)
		zf-H2C2_2	526..551	CDD:404364	7/20 (35%)
		C2H2 Zn finger	542..562	CDD:275368	1/3 (33%)
		zf-H2C2_2	555..579	CDD:404364
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100