DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF175

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_009078.1	Gene:	ZNF175 / 7728	HGNCID:	12964	Length:	711	Species:	Homo sapiens

Alignment Length:	624	Identity:	147/624 - (23%)
Similarity:	243/624 - (38%)	Gaps:	141/624 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NGSNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQE 82
            |..:|..:.|       |.:|.:.|...|:       :...|||.|  .||:...:|
Human   168 NTESNCEYKD-------PGKMIRTRPHLAS-------SQKQPQKCC--LFTESLKLN-------- 208

  Fly    83 AQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDA 147
              |:::...:..|...| ||.:|...|   ..|..::.........             |.|...
Human   209 --LEVNGQNESNDTEQL-DDVVGSGQL---FSHSSSDACSKNIHTG-------------ETFCKG 254

  Fly   148 VDIDEAEEEEEEEEQQQQYDEEVEEPITD------------------------------ESAPPQ 182
            ....:....::..:|.|.:.::..:..::                              ::..||
Human   255 NQCRKVCGHKQSLKQHQIHTQKKPDGCSECGGSFTQKSHLFAQQRIHSVGNLHECGKCGKAFMPQ 319

  Fly   183 LTISY-----------ACKFC----LRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAA 232
            |.:|.           .||.|    ::..|       ||.| ..:|..::||.|.:|...|....
Human   320 LKLSVYLTDHTGDIPCICKECGKVFIQRSE-------LLTH-QKTHTRKKPYKCHDCGKAFFQML 376

  Fly   233 SRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWH 297
            |...|.::...||.:.|..|||.:.....|..|.:.:..|..:.|:.|.|.|..:.:|:.|.:.|
Human   377 SLFRHQRTHSREKLYECSECGKGFSQNSTLIIHQKIHTGERQYACSECGKAFTQKSTLSLHQRIH 441

  Fly   298 NPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGE 362
            :..:.:.|..  |.:.||.:.||:.|:.:|:|   .|...|..|||:||....|..| :|.|.||
Human   442 SGQKSYVCIE--CGQAFIQKAHLIVHQRSHTG---EKPYQCHNCGKSFISKSQLDIH-HRIHTGE 500

  Fly   363 KPYKCANCTEVFASYA----EKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQ 423
            |||:|::|.:.|...:    .::||..|||.         .|..|.:.|:.:..|..|......:
Human   501 KPYECSDCGKTFTQKSHLNIHQKIHTGERHH---------VCSECGKAFNQKSILSMHQRIHTGE 556

  Fly   424 RPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFK 488
            :|                       ::|..|.:.|..||..:.|..:|: .::|:.|..|.|.|.
Human   557 KP-----------------------YKCSECGKAFTSKSQFKEHQRIHT-GEKPYVCTECGKAFN 597

  Fly   489 RAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLH 553
            ...:...|..||.:|:|.||..|||||..|..|..|:.:| :.||.::|..||:::..:..|::|
Human   598 GRSNFHKHQITHTRERPFVCYKCGKAFVQKSELITHQRTH-MGEKPYECLDCGKSFSKKPQLKVH 661

  Fly   554 QRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            ||.|||:..|.|..|.:.|........| |..|...:.:
Human   662 QRIHTGERPYVCSECGKAFNNRSNFNKH-QTTHTRDKSY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	15/68 (22%)
		COG5048	198..>508	CDD:227381	83/313 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/20 (20%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF175	NP_009078.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		KRAB	27..85	CDD:214630
		C2H2 Zn finger	230..246	CDD:275368	2/18 (11%)
		C2H2 Zn finger	255..273	CDD:275368	2/17 (12%)
		COG5048	275..689	CDD:227381	118/461 (26%)
		C2H2 Zn finger	281..300	CDD:275368	0/18 (0%)
		C2H2 Zn finger	309..329	CDD:275368	4/19 (21%)
		C2H2 Zn finger	337..357	CDD:275368	7/27 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	359..362		0/2 (0%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..469	CDD:275368	7/21 (33%)
		C2H2 Zn finger	477..497	CDD:275368	9/20 (45%)
		C2H2 Zn finger	505..525	CDD:275368	3/19 (16%)
		C2H2 Zn finger	533..553	CDD:275368	5/19 (26%)
		C2H2 Zn finger	561..581	CDD:275368	6/19 (32%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		C2H2 Zn finger	617..637	CDD:275368	9/19 (47%)
		C2H2 Zn finger	645..665	CDD:275368	7/19 (37%)
		C2H2 Zn finger	673..693	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100