DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF157

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_003437.2	Gene:	ZNF157 / 7712	HGNCID:	12942	Length:	506	Species:	Homo sapiens

Alignment Length:	521	Identity:	145/521 - (27%)
Similarity:	213/521 - (40%)	Gaps:	96/521 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SLED---DEIGQE--DLEPAEE--HQETETTKPTTTVSAETQPNNTA-----SDPIEIFVDAVDI 150
            |.||   |...||  .|:||:.  |::         |..||..|..:     :.|..||    .:
Human    28 SFEDVAVDFTRQEWHRLDPAQRTMHKD---------VMLETYSNLASVGLCVAKPEMIF----KL 79

  Fly   151 DEAEE--EEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHIN--- 210
            :..||  ..|||.....|..               ::|..|       .|..:....|.|.|
Human    80 ERGEELWILEEESSGHGYSG---------------SLSLLC-------GNGSVGDNALRHDNDLL 122

  Fly   211 -----ASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYH 270
                 .:.|....||  .|...|.:........::...:|...|..|||.|..:.||..|:..:.
Human   123 HHQKIQTLDQNVEYN--GCRKAFHEKTGFVRRKRTPRGDKNFECHECGKAYCRKSNLVEHLRIHT 185

  Fly   271 SETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKS 335
            .|..:||..|.|.|..|..|..|.|.|..:|.|:|..  |.:.|..:..|:.|..||:|   .:.
Human   186 GERPYECGECAKTFSARSYLIAHQKTHTGERPFECNE--CGKSFGRKSQLILHTRTHTG---ERP 245

  Fly   336 EHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSEC 400
            ..|..|||||....||..| .|.|.|||||:|:.|.:.|    ..:|.:.:.||.: |..:..||
Human   246 YECTECGKTFSEKATLTIH-QRTHTGEKPYECSECGKTF----RVKISLTQHHRTH-TGEKPYEC 304

  Fly   401 MLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALE 465
            ..|.:.|.::..|..|......::|                       ::||.|.:.|.||..|.
Human   305 GECGKNFRAKKSLNQHQRIHTGEKP-----------------------YECGECGKFFRMKMTLN 346

  Fly   466 RHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEV 530
            .|...|: .::|:.|..|.|.|:....:..|.:.|..|||..|:.||.||.:|..|.:|:..|..
Human   347 NHQRTHT-GEKPYQCNECGKSFRVHSSLGIHQRIHTGEKPYECNECGNAFYVKARLIEHQRMHSG 410

  Fly   531 LEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSAD 595
             ||.::|:.||:.:..:|||..|:|||||:..|:|..|...|...::|..| |:.|...:|....
Human   411 -EKPYECSECGKIFSMKKSLCQHRRTHTGEKPYECSECGNAFYVKVRLIEH-QRIHTGERPFECQ 473

  Fly   596 Q 596
            :
Human   474 E 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	88/317 (28%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF157	NP_003437.2	KRAB	27..87	CDD:214630	19/71 (27%)
		KRAB	27..66	CDD:279668	14/46 (30%)
		C2H2 Zn finger	137..156	CDD:275368	3/20 (15%)
		COG5048	159..499	CDD:227381	111/353 (31%)
		C2H2 Zn finger	164..184	CDD:275368	8/19 (42%)
		zf-H2C2_2	176..200	CDD:290200	8/23 (35%)
		C2H2 Zn finger	192..212	CDD:275368	8/19 (42%)
		zf-H2C2_2	204..229	CDD:290200	9/26 (35%)
		C2H2 Zn finger	220..240	CDD:275368	5/21 (24%)
		zf-H2C2_2	236..256	CDD:290200	9/22 (41%)
		C2H2 Zn finger	248..268	CDD:275368	10/20 (50%)
		zf-H2C2_2	261..283	CDD:290200	11/22 (50%)
		C2H2 Zn finger	276..296	CDD:275368	6/23 (26%)
		zf-H2C2_2	288..311	CDD:290200	6/23 (26%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		zf-H2C2_2	316..339	CDD:290200	6/45 (13%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..367	CDD:290200	7/22 (32%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		zf-H2C2_2	372..395	CDD:290200	8/22 (36%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		zf-H2C2_2	401..424	CDD:290200	8/23 (35%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		zf-H2C2_2	431..451	CDD:290200	9/19 (47%)
		C2H2 Zn finger	444..464	CDD:275368	6/20 (30%)
		zf-H2C2_2	457..479	CDD:290200	5/19 (26%)
		zf-C2H2	470..492	CDD:278523	0/5 (0%)
		C2H2 Zn finger	472..492	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100