DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp934

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_017171126.1	Gene:	Zfp934 / 77117	MGIID:	1924367	Length:	491	Species:	Mus musculus

Alignment Length:	528	Identity:	140/528 - (26%)
Similarity:	224/528 - (42%)	Gaps:	82/528 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DASSLEDDEIG--QED---LEPAE----EHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDI 150
            :|.:.||..:.  ||:   |:|::    :|...||.:....:....:..|     ||....:...
Mouse    20 NAVTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIGFNWEAQN-----IEEHCQSSRR 79

  Fly   151 DEAEEEEEEEEQQQQYDE-------------EVEEPITDESAPPQLTISYACKFCLRPQENYQLQ 202
            ....|..:..|:..:|.:             :..|.|..|..|.:   ...|...:.|..:.|:.
Mouse    80 HRRCERSQSAEKPSEYTQRDKAFALSAHSHAQRHERIHTEKIPSE---DIHCVEDVLPYTSLQVH 141

  Fly   203 QLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSS---HV-EKQHACGVCGKKYGDRHNLR 263
            :       .:...::||.|.:|...|    ::..|||..   |. |:...|..|.|.:..:|:|:
Mouse   142 K-------RTQTGQKPYECKQCGKGF----AKPSHLKRHERYHTGEQPFTCNECDKVFSFKHHLQ 195

  Fly   264 HHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHS 328
            .|:.....|..|:|.||:|.|.....|..|.:.|..::.:||  ..|::.|..:.:|..|...||
Mouse   196 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHS 258

  Fly   329 GTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLT 393
            |   .|...|..|.|||.....|:.|| |.|.|||||||..|.:.|:.|     :.|:.||...|
Mouse   259 G---EKPYKCDQCDKTFSEKCHLQKHI-RIHTGEKPYKCNQCDKAFSQY-----NTLKTHRRTHT 314

  Fly   394 AIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRF 458
            ..:..:|..|.:.||....|..|......::|                       ::|..|.:.|
Mouse   315 GEKPYKCNQCDKAFSQYGHLQTHRRTHTGEKP-----------------------YKCNQCDKAF 356

  Fly   459 NMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQ 523
            :..:.|:.|...|: .::|:.|..|.|.|.....::.||:.|..|||..|:.|.|||:....|..
Mouse   357 SQYNTLKTHRRTHT-GEKPYKCNQCDKAFSEKCSLQRHIRIHTGEKPYKCNQCDKAFSQYSTLQT 420

  Fly   524 HRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAA 588
            ||.:| ..||.:|||.|.:|:....:|:.|:|||||:..|||:.|.:.|.....|:.|: :.|..
Mouse   421 HRRTH-TGEKPYKCNQCDKAFSQYSNLQTHRRTHTGEKPYKCNQCDKAFSMKCNLQNHV-RIHTG 483

  Fly   589 SQPHSADQ 596
            .:|...:|
Mouse   484 QKPFKCNQ 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/313 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp934	XP_017171126.1	KRAB	22..62	CDD:366587	9/39 (23%)
		C2H2 Zn finger	99..117	CDD:275368	1/17 (6%)
		C2H2 Zn finger	153..173	CDD:275368	6/23 (26%)
		zf-H2C2_2	165..189	CDD:372612	8/23 (35%)
		C2H2 Zn finger	181..201	CDD:275368	6/19 (32%)
		COG5048	196..>489	CDD:227381	101/329 (31%)
		C2H2 Zn finger	209..229	CDD:275368	7/19 (37%)
		C2H2 Zn finger	237..257	CDD:275368	5/21 (24%)
		C2H2 Zn finger	265..285	CDD:275368	9/20 (45%)
		C2H2 Zn finger	293..313	CDD:275368	7/24 (29%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		C2H2 Zn finger	349..369	CDD:275368	5/19 (26%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..481	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100