DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF140

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_011533135.1	Gene:	ZNF140 / 7699	HGNCID:	12925	Length:	458	Species:	Homo sapiens

Alignment Length:	401	Identity:	115/401 - (28%)
Similarity:	165/401 - (41%)	Gaps:	82/401 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 CLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKY 256
            |....|..|..|..:..:..||               |:|.::  |:..|.||:.:.|..|||.:
Human   124 CKDHTEMLQENQGCIRKVTVSH---------------QEALAQ--HMNISTVERPYGCHECGKTF 171

  Fly   257 GDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLM 321
            |                        :||    ||..|.:.|..::.:.|:.  |.:.|....:|:
Human   172 G------------------------RRF----SLVLHQRTHTGEKPYACKE--CGKTFSQISNLV 206

  Fly   322 CHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLE 386
            .|:..|:|   :|...|..|.|||.:|..|..| .|.|.|||||:|..|.:.|:     |...|.
Human   207 KHQMIHTG---KKPHECKDCNKTFSYLSFLIEH-QRTHTGEKPYECTECGKAFS-----RASNLT 262

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQC 451
            ||:......::..|..|.:.|||..:||.|......::|                       ::|
Human   263 RHQRIHIGKKQYICRKCGKAFSSGSELIRHQITHTGEKP-----------------------YEC 304

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|.:.|...|.|.||.::|:.| .|:.|..|.|.|:....:..|.:.|..||...||.|||.|.
Human   305 IECGKAFRRFSHLTRHQSIHTTK-TPYECNECRKAFRCHSFLIKHQRIHAGEKLYECDECGKVFT 368

  Fly   517 LKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ....|.||..|| ..||.:.|..|.:|:....||.||||||||:..|.|.:|.:.|.....|..|
Human   369 WHASLIQHTKSH-TGEKPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKVCNKSFSWSSNLAKH 432

  Fly   582 MQKAHAASQPH 592
             |:.|....|:
Human   433 -QRTHTLDNPY 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	78/309 (25%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF140	XP_011533135.1	KRAB	6..66	CDD:214630
		KRAB	6..45	CDD:279668
		COG5048	160..>453	CDD:227381	103/348 (30%)
		C2H2 Zn finger	164..184	CDD:275368	10/47 (21%)
		zf-H2C2_2	176..201	CDD:290200	7/26 (27%)
		C2H2 Zn finger	192..212	CDD:275368	5/21 (24%)
		zf-H2C2_2	204..229	CDD:290200	10/27 (37%)
		C2H2 Zn finger	220..240	CDD:275368	9/20 (45%)
		zf-H2C2_2	233..257	CDD:290200	12/29 (41%)
		C2H2 Zn finger	248..268	CDD:275368	7/24 (29%)
		zf-H2C2_2	260..285	CDD:290200	6/24 (25%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		zf-H2C2_2	288..313	CDD:290200	7/47 (15%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		zf-H2C2_2	372..397	CDD:290200	10/25 (40%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	416..436	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100