DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF136

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_003428.1	Gene:	ZNF136 / 7695	HGNCID:	12920	Length:	540	Species:	Homo sapiens

Alignment Length:	585	Identity:	162/585 - (27%)
Similarity:	231/585 - (39%)	Gaps:	125/585 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GSN-NSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQE 82
            |.| .||.|:..:.....|:...|..||||.||.        :||..   .|.|.
Human    60 GRNLRSHMLERLYQTKDGSQRGGIFSQFANQNLS--------KKIPG---VKLCE---------- 103

  Fly    83 AQLKLSHIYDKIDASSLEDDEIGQEDL----------EPAEEHQETETTKPTTTVSAETQPNNTA 137
                 |.:|.::        .:||..|          ||.|..:..|  ||.|        .|..
Human   104 -----SIVYGEV--------SMGQSSLNRHIKDHSGHEPKEYQEYGE--KPDT--------RNQC 145

  Fly   138 SDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPI-TDESAPPQLTISYACKFCLRPQENYQL 201
            ..|.                     ...:.....|.| |.|..       |.||.|  .:..:.|
Human   146 WKPF---------------------SSHHSFRTHEIIHTGEKL-------YDCKEC--GKTFFSL 180

  Fly   202 QQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHV 266
            :: :..|| .:|....||.|..|...|...:....|.:|...||.:.|..|||.:....::|.|:
Human   181 KR-IRRHI-ITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGEKPYECQECGKAFTCITSVRRHM 243

  Fly   267 EKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTS 331
            .|:..:..::|.:|.|.|::..|...|.:.|..::.|||:.  |.:.|.....|..||.||:|
Human   244 IKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTGEKPFKCKQ--CGKAFSCSPTLRIHERTHTG-- 304

  Fly   332 SRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIE 396
             .|...|..|||.|.:|.:||.| .|.|.||||:.|..|.:.|.|.:..:||  ||..   |..:
Human   305 -EKPYECKQCGKAFSYLPSLRLH-ERIHTGEKPFVCKQCGKAFRSASTFQIH--ERTH---TGEK 362

  Fly   397 RSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMK 461
            ..||..|.:.||..|.:..||    ::..|                   .|.::|..|.:.|:..
Human   363 PYECKECGEAFSCIPSMRRHM----IKHTG-------------------EGPYKCKVCGKPFHSL 404

  Fly   462 SALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRL 526
            |....|...|: .::|:.|.||.|.|..:..::.|.:||..|||..|..|||||:.......|.:
Human   405 SPFRIHERTHT-GEKPYVCKHCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEM 468

  Fly   527 SHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            .| ..||.|:|..||:|:....|.|||:|||||:..|.|..|.:.:......:.|| ..||...|
Human   469 IH-TGEKPFECKRCGKAFRSSSSFRLHERTHTGQKPYHCKECGKAYSCRASFQRHM-LTHAEDGP 531

Fly 592 591
Human 532 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	17/68 (25%)
		COG5048	198..>508	CDD:227381	91/309 (29%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	2/16 (13%)
ZNF136	NP_003428.1	KRAB	3..44	CDD:307490
		C2H2 Zn finger	143..162	CDD:275368	3/39 (8%)
		COG5048	157..526	CDD:227381	128/416 (31%)
		C2H2 Zn finger	170..190	CDD:275368	6/23 (26%)
		C2H2 Zn finger	198..218	CDD:275368	4/19 (21%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		C2H2 Zn finger	282..302	CDD:275368	6/21 (29%)
		C2H2 Zn finger	310..330	CDD:275368	10/20 (50%)
		C2H2 Zn finger	338..358	CDD:275368	8/21 (38%)
		C2H2 Zn finger	366..386	CDD:275368	7/23 (30%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		C2H2 Zn finger	506..526	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100