DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF121

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001008727.1	Gene:	ZNF121 / 7675	HGNCID:	12904	Length:	390	Species:	Homo sapiens

Alignment Length:	468	Identity:	124/468 - (26%)
Similarity:	192/468 - (41%)	Gaps:	109/468 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 EDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVE 171
            |:.|...||         :.::|.....||.        |..|.||             |.|..
Human    15 ENGEIFSEH---------SCLNAHMGTENTG--------DTYDCDE-------------YGENF- 48

  Fly   172 EPITDESAPPQLTISY--ACK--FCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAA 232
             |:...|||...|:|.  .|:  |.|.|..:.:           :...::.:...:||..|.|.:
Human    49 -PMLHNSAPAGETLSVLNQCRKAFSLPPNVHQR-----------TWIGDKSFEYSDCEEAFVDQS 101

  Fly   233 SRTVHLKSSHV---------EKQHACGVCGKKYGDRHNLRHHVE-KYHS-ETDFECALCEKRFYT 286
                ||:::.:         :||     ||:.:  .::..|.|. |.|: |..:||..|.|.|..
Human   102 ----HLQANRITHNGETLYEQKQ-----CGRAF--TYSTSHAVSVKMHTVEKPYECKECGKFFRY 155

  Fly   287 RKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTL 351
            ...||.||:.|..::.::|:.  |.:.|....||:.|...|:|   .|...|..||:.|.....|
Human   156 SSYLNSHMRTHTGEKPYECKE--CGKCFTVSSHLVEHVRIHTG---EKPYQCKECGRAFAGRSGL 215

  Fly   352 RWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHH 416
            ..|: |.|.|||||:|..|.:.:     .|.::|..|.:..|..:..||.:|.:.|.|...|.:|
Human   216 TKHV-RIHTGEKPYECNECGKAY-----NRFYLLTEHFKTHTEEKPFECKVCGKSFRSSSCLKNH 274

  Fly   417 MSAEHLQRPGAPIIANNKRVLQQKRERQYSGL--FQCGSCSQRFNMKSALERHAAVHSEKDRPHA 479
            .                         |.::|:  ::|..|.:.|.:.|:|..|..:|: .::|:.
Human   275 F-------------------------RIHTGIKPYKCKECGKAFTVSSSLHNHVKIHT-GEKPYE 313

  Fly   480 CPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY 544
            |..|.|.|..:..:..||:||..|||.:|..|||.|.....|.:|...| ..||.:.||.||:||
Human   314 CKDCGKAFATSSQLIEHIRTHTGEKPYICKECGKTFRASSHLQKHVRIH-TGEKPYICNECGKAY 377

  Fly   545 LFEKSLRLHQRTH 557
            .....|..|.:||
Human   378 NRFYLLTKHLKTH 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	81/322 (25%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	4/20 (20%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF121	NP_001008727.1	C2H2 Zn finger	65..82	CDD:275368	4/27 (15%)
		COG5048	<85..270	CDD:227381	58/206 (28%)
		C2H2 Zn finger	91..110	CDD:275368	6/22 (27%)
		C2H2 Zn finger	119..138	CDD:275368	7/25 (28%)
		zf-C2H2	144..166	CDD:278523	9/21 (43%)
		C2H2 Zn finger	146..166	CDD:275368	8/19 (42%)
		zf-H2C2_2	158..182	CDD:290200	7/25 (28%)
		C2H2 Zn finger	174..194	CDD:275368	6/21 (29%)
		zf-H2C2_2	186..210	CDD:290200	9/26 (35%)
		C2H2 Zn finger	202..222	CDD:275368	7/20 (35%)
		zf-H2C2_2	215..239	CDD:290200	11/29 (38%)
		COG5048	<226..388	CDD:227381	55/193 (28%)
		C2H2 Zn finger	230..250	CDD:275368	5/24 (21%)
		zf-H2C2_2	243..267	CDD:290200	7/23 (30%)
		C2H2 Zn finger	258..278	CDD:275368	7/44 (16%)
		zf-H2C2_2	271..294	CDD:290200	6/47 (13%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		zf-H2C2_2	301..323	CDD:290200	7/22 (32%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		zf-H2C2_2	327..349	CDD:290200	11/21 (52%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	11/25 (44%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100