DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF221

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001284517.1	Gene:	ZNF221 / 7638	HGNCID:	13014	Length:	617	Species:	Homo sapiens

Alignment Length:	642	Identity:	161/642 - (25%)
Similarity:	253/642 - (39%)	Gaps:	148/642 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ISPN-DGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEE- 114
            |||: :.|...:|     ||..:.......:||      :..|..|....::|:|.  |:||:.
Human     2 ISPSLELLHSGLC-----KFPEVEGKMTTFKEA------VTFKDVAVVFTEEELGL--LDPAQRK 53

  Fly   115 ---------------------HQET-------ETTKPTTTVSAETQPNNTASDPIEIFVDAVDID 151
                                 ||:|       :..|..||    :|....:...|:|.::.|  .
Human    54 LYRDVMLENFRNLLSVGNQPFHQDTFHFLGKEKFWKMKTT----SQREGNSGGKIQIEMETV--P 112

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPE 216
            ||...||...||      :.|.|..:....|.:|..:.:|........|::    ..::.||..:
Human   113 EAGPHEEWSCQQ------IWEQIASDLTRSQNSIRNSSQFFKEGDVPCQIE----ARLSISHVQQ 167

  Fly   217 QPYNCPECEARFQDAASRTVHLKSSHVEKQHACG----------------------------VCG 253
            :||.|.||:..|.|.:...:|.:|...||.|.||                            |||
Human   168 KPYRCNECKQSFSDVSVFDLHQQSHSGEKSHTCGECGKSFCYSPALHIHQRVHMGEKCYKCDVCG 232

  Fly   254 KKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            |::....:|:.|...:..|..|:|..|.|.|::|.:||.|.|.|..::.:.|..  |.:.||...
Human   233 KEFNQSSHLQTHQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYNCEE--CGKAFIHDS 295

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH 383
            .|..|:..|:|   .|...|..|||:|.....|..| ...|.||||::|..|.:.|...:....|
Human   296 QLQEHQRIHTG---EKPFKCDICGKSFRVRSRLNRH-SMVHTGEKPFRCDTCGKNFRQRSALNSH 356

  Fly   384 MLERHRENLTAIERS--ECMLCRQPFSSEPDLIHHMSAEHLQRP-----------GAPIIANNKR 435
                   ::..||..  :|..|.:.|....|...|......::|           .:..:.|:::
Human   357 -------SMVHIEEKPYKCEQCGKGFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNHQQ 414

  Fly   436 VLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIK 498
            |        :||  .|:|..|.:.|...|....|...|: .::|:.|..|.|.:||..|:::|.:
Human   415 V--------HSGQKSFKCEECGKGFYTNSRRSSHQRSHN-GEKPYNCEECGKDYKRRLDLEFHQR 470

  Fly   499 THEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYY 563
            .|..|:|..|..|||:|.....|.:|:..|.. ||.|||..||:.:.....|..||..|||:..|
Human   471 VHTGERPYNCKECGKSFGWASCLLKHQRLHSG-EKPFKCEECGKRFTQSSQLHSHQTCHTGEKLY 534

  Fly   564 KCDLCQERFVTHIKLKTHMQKAHAASQP----------------------HSADQPL 598
            ||:.|::.:.:...|..| |:.|...:|                      ||.::||
Human   535 KCEQCEKGYNSKFNLDMH-QRVHGGERPYNCKECGKSFGWASCLLKHQRLHSGEKPL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	9/35 (26%)
		COG5048	198..>508	CDD:227381	90/352 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	8/47 (17%)
		C2H2 Zn finger	277..297	CDD:275368	9/19 (47%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF221	NP_001284517.1	KRAB	30..70	CDD:307490	7/41 (17%)
		COG5048	166..576	CDD:227381	117/433 (27%)
		C2H2 Zn finger	172..192	CDD:275368	6/19 (32%)
		C2H2 Zn finger	200..220	CDD:275368	2/19 (11%)
		C2H2 Zn finger	228..248	CDD:275368	6/19 (32%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	6/21 (29%)
		C2H2 Zn finger	312..332	CDD:275368	7/20 (35%)
		C2H2 Zn finger	340..360	CDD:275368	4/26 (15%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		C2H2 Zn finger	396..416	CDD:275368	2/27 (7%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	536..556	CDD:275368	5/20 (25%)
		C2H2 Zn finger	564..584	CDD:275368	0/19 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000