DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF84

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	559	Identity:	153/559 - (27%)
Similarity:	236/559 - (42%)	Gaps:	98/559 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DCFTKFCSIN----AFRLACQEAQLK---LSHIYD----KIDASSLEDDEIGQEDLEPAEEHQET 118
            |.|.|..::|    ..|.:..|..|.   |.|..|    |.|....|.|:....|
Human   108 DAFGKNFNLNMNFVPLRKSNSEGDLDGLILKHHLDLLIPKGDYGKAESDDFNVFD---------- 162

  Fly   119 ETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEE----QQQQYDEEVEEPITDE-- 177
                   .....::|.:|     :.::...|.|:.:|..::.:    .:.:..|::.|  ..|
Human   163 -------NFFLHSKPEDT-----DTWLKYYDCDKYKESYKKSQIIIYHRNRLGEKLYE--CSECR 213

  Fly   178 ---SAPPQL---------TISYACKFCLR--PQENYQLQQLLLEHINASHDPEQPYNCPECEARF 228
               |..|.|         .|::.|..|.:  ||::    |.:..|  .:|..|:||||.:|...|
Human   214 KRFSKKPSLIKHQSRHIRDIAFGCGNCGKTFPQKS----QFITHH--RTHTGEKPYNCSQCGKAF 272

  Fly   229 QDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYH 293
            ...:..|.|.::...||.:.||.|||.:..:.:|..|...:..|..:.|..|.:.|..:.:|..|
Human   273 SQKSQLTSHQRTHTGEKPYECGECGKAFSRKSHLISHWRTHTGEKPYGCNECGRAFSEKSNLINH 337

  Fly   294 MKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQ 358
            .:.|..::.|:||.  |.:.|..:..|:.|..||:||   |...|..|.|.|.....|..| ...
Human   338 QRIHTGEKPFECRE--CGKAFSRKSQLVTHHRTHTGT---KPFGCSDCRKAFFEKSELIRH-QTI 396

  Fly   359 HGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQ 423
            |.|||||:|:.|.:.|...:.     |..|:...|..:...|:.|.:.||.:..||.|......:
Human   397 HTGEKPYECSECRKAFRERSS-----LINHQRTHTGEKPHGCIQCGKAFSQKSHLISHQMTHTGE 456

  Fly   424 RPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFK 488
            :|                       |.|..|.:.|:.||.|.||...|: .::|:.|..|.|.|.
Human   457 KP-----------------------FICSKCGKAFSRKSQLVRHQRTHT-GEKPYECSECGKAFS 497

  Fly   489 RAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLH 553
            ....:..|.:.|..|||.||..|||||..|..|..|:.:| ..||.::|:.||:|:..:.||..|
Human   498 EKLSLTNHQRIHTGEKPYVCSECGKAFCQKSHLISHQRTH-TGEKPYECSECGKAFGEKSSLATH 561

  Fly   554 QRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            ||||||:..|:|..|::.|....:|.|| |:.|...:|:
Human   562 QRTHTGEKPYECRDCEKAFSQKSQLNTH-QRIHTGEKPY 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	7/28 (25%)
		COG5048	198..>508	CDD:227381	86/309 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368	4/19 (21%)
		C2H2 Zn finger	237..257	CDD:275368	6/25 (24%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		zf-H2C2_2	278..302	CDD:316026	9/23 (39%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		COG5048	317..724	CDD:227381	100/320 (31%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		C2H2 Zn finger	349..369	CDD:275368	6/21 (29%)
		C2H2 Zn finger	377..397	CDD:275368	6/20 (30%)
		C2H2 Zn finger	405..425	CDD:275368	5/24 (21%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		C2H2 Zn finger	517..537	CDD:275368	9/19 (47%)
		C2H2 Zn finger	545..565	CDD:275368	9/19 (47%)
		C2H2 Zn finger	573..593	CDD:275368	7/20 (35%)
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010