DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF74

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001243453.1	Gene:	ZNF74 / 7625	HGNCID:	13144	Length:	644	Species:	Homo sapiens

Alignment Length:	377	Identity:	116/377 - (30%)
Similarity:	168/377 - (44%)	Gaps:	39/377 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 EQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALC 280
            |..:.|.||...|:.::|.|:|.:....||.:.|..|||.:....||..|...:..|..|.|..|
Human   245 EGEFVCGECGKAFRQSSSLTLHRRWHSREKAYKCDECGKAFTWSTNLLEHRRIHTGEKPFFCGEC 309

  Fly   281 EKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTF 345
            .|.|....|||.|.:.|..:|.:||  |.||:.|.....|..|...|:|   .|...||.|||.|
Human   310 GKAFSCHSSLNVHQRIHTGERPYKC--SACEKAFSCSSLLSMHLRVHTG---EKPYRCGECGKAF 369

  Fly   346 IHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERS-ECMLCRQPFSS 409
            .....|..| :|.|.|||||:|.:|.:.|..::...:|      |.:.:.::. :|..|.:.|:|
Human   370 NQRTHLTRH-HRIHTGEKPYQCGSCGKAFTCHSSLTVH------EKIHSGDKPFKCSDCEKAFNS 427

  Fly   410 EPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEK 474
            ...|..|......::|                       |:|..|.:.|:..:.|..|..:|| .
Human   428 RSRLTLHQRTHTGEKP-----------------------FKCADCGKGFSCHAYLLVHRRIHS-G 468

  Fly   475 DRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNV 539
            ::|..|..|.|.|.....:..|.:.|..|||..|..|.|||:....|..|:..| ..||.:||:.
Human   469 EKPFKCNECGKAFSSHAYLIVHRRIHTGEKPFDCSQCWKAFSCHSSLIVHQRIH-TGEKPYKCSE 532

  Fly   540 CGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            ||||:.....|..||:.|:|:..:||:.|.|.|.....|..| |:.|:..:|
Human   533 CGRAFSQNHCLIKHQKIHSGEKSFKCEKCGEMFNWSSHLTEH-QRLHSEGKP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/292 (29%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF74	NP_001243453.1	KRAB	43..103	CDD:214630
		COG5048	<248..395	CDD:227381	56/152 (37%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		COG5048	<331..511	CDD:227381	61/215 (28%)
		C2H2 Zn finger	334..354	CDD:275368	7/21 (33%)
		C2H2 Zn finger	362..382	CDD:275368	9/20 (45%)
		C2H2 Zn finger	390..410	CDD:275368	5/25 (20%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..494	CDD:275368	5/19 (26%)
		C2H2 Zn finger	502..522	CDD:275368	7/19 (37%)
		zf-H2C2_2	514..539	CDD:372612	11/25 (44%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100