DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF41

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001311084.1	Gene:	ZNF41 / 7592	HGNCID:	13107	Length:	821	Species:	Homo sapiens

Alignment Length:	650	Identity:	156/650 - (24%)
Similarity:	248/650 - (38%)	Gaps:	185/650 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FENGSNNSHFLDLHHPNCWPSEMAQI---------------RLQFANWNLKISPNDGLPQKICSD 65
            |.||:|..     |.|:...:|.|:.               ..|....:.||.|.:.|  .:|::
Human   260 FGNGNNFP-----HSPSSTKNENAKTGANSCEHDHYEKHLSHKQAPTHHQKIHPEEKL--YVCTE 317

  Fly    66 CFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAE 130
            |...|              .:.||::                      |||.
Human   318 CVMGF--------------TQKSHLF----------------------EHQR------------- 333

  Fly   131 TQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTI---------S 186
                               |...|:..|.::..:.:.::           ||:.:         .
Human   334 -------------------IHAGEKSRECDKSNKVFPQK-----------PQVDVHPSVYTGEKP 368

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            |.|..|   .:.:.|:..|:.| ...|..::||.|.||...|...:....||:....||.:.|..
Human   369 YLCTQC---GKVFTLKSNLITH-QKIHTGQKPYKCSECGKAFFQRSDLFRHLRIHTGEKPYECSE 429

  Fly   252 CGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFIS 316
            |||.:....:|..|.:.:..|..:||..|.|.|..:.:|..|.:.|..::.:.|  :.|.:.||.
Human   430 CGKGFSQNSDLSIHQKTHTGEKHYECNECGKAFTRKSALRMHQRIHTGEKPYVC--ADCGKAFIQ 492

  Fly   317 QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKR 381
            :.|...|:..|:|   .|...|..|||:|.....|..| .|.|.|||||.|..|.:||.
Human   493 KSHFNTHQRIHTG---EKPYECSDCGKSFTKKSQLHVH-QRIHTGEKPYICTECGKVFT------ 547

  Fly   382 IHMLERHRENLTAIERSE-------CMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANN 433
                  ||.|||..:::.       |..|.:.|:.:.:||.|......::|      |...|..:
Human   548 ------HRTNLTTHQKTHTGEKPYMCAECGKAFTDQSNLIKHQKTHTGEKPYKCNGCGKAFIWKS 606

  Fly   434 KRVLQQKR---ERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRF-------- 487
            :..:.||.   ||.|    :|..|.:.|..||.|..|..:|: .::|:.||.|.|.|
Human   607 RLKIHQKSHIGERHY----ECKDCGKAFIQKSTLSVHQRIHT-GEKPYVCPECGKAFIQKSHFIA 666

  Fly   488 ---------------------KRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVL 531
                                 |::| ::.|.|.|..||||:|..|||||..:..|..|:..| ..
Human   667 HHRIHTGEKPYECSDCGKCFTKKSQ-LRVHQKIHTGEKPNICAECGKAFTDRSNLITHQKIH-TR 729

  Fly   532 EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ||.::|..||:.:.::..|.:||::|||:.:|:|..|.:.|:....|..| |..|...:|::..:
Human   730 EKPYECGDCGKTFTWKSRLNIHQKSHTGERHYECSKCGKAFIQKATLSMH-QIIHTGKKPYACTE 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	16/85 (19%)
		COG5048	198..>508	CDD:227381	98/354 (28%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	9/48 (19%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF41	NP_001311084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		KRAB	69..129	CDD:214630
		KRAB	69..108	CDD:279668
		C2H2 Zn finger	315..335	CDD:275368	8/87 (9%)
		COG5048	346..768	CDD:227381	126/461 (27%)
		C2H2 Zn finger	371..391	CDD:275368	5/23 (22%)
		zf-H2C2_2	383..406	CDD:290200	8/23 (35%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		zf-H2C2_2	411..436	CDD:290200	8/24 (33%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..464	CDD:290200	8/24 (33%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		zf-H2C2_2	467..492	CDD:290200	6/26 (23%)
		C2H2 Zn finger	483..503	CDD:275368	6/21 (29%)
		zf-H2C2_2	495..519	CDD:290200	9/26 (35%)
		C2H2 Zn finger	511..531	CDD:275368	8/20 (40%)
		zf-H2C2_2	526..548	CDD:290200	12/34 (35%)
		C2H2 Zn finger	539..559	CDD:275368	9/31 (29%)
		zf-H2C2_2	551..575	CDD:290200	5/23 (22%)
		C2H2 Zn finger	567..587	CDD:275368	6/19 (32%)
		zf-H2C2_2	579..602	CDD:290200	5/22 (23%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		zf-H2C2_2	636..660	CDD:290200	9/24 (38%)
		C2H2 Zn finger	651..671	CDD:275368	5/19 (26%)
		zf-C2H2	677..699	CDD:278523	4/22 (18%)
		C2H2 Zn finger	679..699	CDD:275368	4/20 (20%)
		C2H2 Zn finger	707..727	CDD:275368	8/19 (42%)
		zf-H2C2_2	719..743	CDD:290200	8/24 (33%)
		C2H2 Zn finger	735..755	CDD:275368	6/19 (32%)
		C2H2 Zn finger	763..783	CDD:275368	6/20 (30%)
		C2H2 Zn finger	791..811	CDD:275368	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100