DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF37A

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001007095.1	Gene:	ZNF37A / 7587	HGNCID:	13102	Length:	561	Species:	Homo sapiens

Alignment Length:	452	Identity:	121/452 - (26%)
Similarity:	181/452 - (40%)	Gaps:	92/452 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 EEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQL-QQLLLEHINASHDPEQPYN 220
            ::...::..|..|..|.|.:||            ..|..|..|.. |:|.|..|..:|.......
Human   192 QQTHPRENHYGNECGENIFEES------------ILLEHQSVYPFSQKLNLTPIQRTHSINNIIE 244

  Fly   221 CPECEARFQDAASRTVHLKS-SHV-EKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKR 283
            ..||...|.:  ...:||:. :|. ||.:.|..|||.:..:.....|...:.....:||..|.|.
Human   245 YNECGTFFSE--KLVLHLQQRTHTGEKPYECHECGKTFTQKSAHTRHQRTHTGGKPYECHECGKT 307

  Fly   284 FYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHL 348
            ||....|..|.:.|..:|.:.                 |||                |||:|...
Human   308 FYKNSDLIKHQRIHTGERPYG-----------------CHE----------------CGKSFSEK 339

  Fly   349 KTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDL 413
            .||..| .|.|.|||||:|..|.:.|:..:     :|..|::..|..:..||..|.:.|..:.||
Human   340 STLTQH-QRTHTGEKPYECHECGKTFSFKS-----VLTVHQKTHTGEKPYECYACGKAFLRKSDL 398

  Fly   414 IHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPH 478
            |.|......::|                       ::|..|.:.|:.||.|.:|...|: .::|:
Human   399 IKHQRIHTGEKP-----------------------YECNECGKSFSEKSTLTKHLRTHT-GEKPY 439

  Fly   479 ACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRA 543
            .|..|.|.|........|::.|..|||..|:.|||.|..|..|..|:.:| :.:|.:.||.||::
Human   440 ECIQCGKFFCYYSGFTEHLRRHTGEKPFGCNECGKTFRQKSALIVHQRTH-IRQKPYGCNQCGKS 503

  Fly   544 YLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQPLDDLINIV 605
            :..:..|..|.|||||:..|:|::|.:.|....||..| |:.|....|          ||:|
Human   504 FCVKSKLIAHHRTHTGEKPYECNVCGKSFYVKSKLTVH-QRIHLGRNP----------INVV 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	79/312 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	3/21 (14%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF37A	NP_001007095.1	KRAB	8..68	CDD:214630
		C2H2 Zn finger	148..164	CDD:275368
		C2H2 Zn finger	246..265	CDD:275368	5/20 (25%)
		COG5048	<269..421	CDD:227381	50/213 (23%)
		C2H2 Zn finger	273..293	CDD:275368	5/19 (26%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		C2H2 Zn finger	329..349	CDD:275368	11/36 (31%)
		C2H2 Zn finger	357..377	CDD:275368	5/24 (21%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..448	CDD:316026	7/22 (32%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		COG5048	492..>552	CDD:227381	22/70 (31%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100