DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF182

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001171570.1	Gene:	ZNF182 / 7569	HGNCID:	13001	Length:	639	Species:	Homo sapiens

Alignment Length:	555	Identity:	155/555 - (27%)
Similarity:	240/555 - (43%)	Gaps:	90/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EIGQEDLEPAEEHQETE-----------TTKPTTTVSA----------ETQPNNTAS----DPIE 142
            |:.|.|.:...:||:.:           ..|...|.||          ....|..||    |..|
Human    97 EVCQVDEQIERQHQDDQDKCLLMQVGFSDKKTIITKSARDCHEFGNILHLSTNLVASIQRPDKHE 161

  Fly   143 IF----VDAVDI---DEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFC---LRPQE 197
            .|    ||.:|:   ..||.:.:....:..:..|.|:  |:....|     |..|.|   ||.::
Human   162 SFGNNMVDNLDLFSRSSAENKYDNGCAKLFFHTEYEK--TNPGMKP-----YGYKECGKGLRRKK 219

  Fly   198 NYQLQQL----------------------LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKS 240
            ...|.|.                      |:.|.. :|..|:|:.|.||...|...:...:||::
Human   220 GLSLHQRIKNGEKPFECTACRKTFSKKSHLIVHWR-THTGEKPFGCTECGKAFSQKSQLIIHLRT 283

  Fly   241 SHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKC 305
            ...|:...|..|||.:.::..:..|...:..|..:||..|.|.|..:.:|..|.|.|..::.::|
Human   284 HTGERPFECPECGKAFREKSTVIIHYRTHTGEKPYECNECGKAFTQKSNLIVHQKTHTGEKTYEC 348

  Fly   306 RHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANC 370
              :.|...||.:..|:.|.:||:|   :|...|..|.|||....||..| .|.|.||||:||..|
Human   349 --TKCGESFIQKLDLIIHHSTHTG---KKPHECNECKKTFSDKSTLIIH-QRTHTGEKPHKCTEC 407

  Fly   371 TEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANN-K 434
            .:   |:.||...::  |:...|..:..||.:|.:.|:.:.:|..|......::   |...|. :
Human   408 GK---SFNEKSTLIV--HQRTHTGEKPYECDVCGKTFTQKSNLGVHQRTHSGEK---PFECNECE 464

  Fly   435 RVLQQK-----RERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQD 492
            :...||     .:|.::|  .::|..|.:.|:.||.|..|...|:| ::|:.|..|.|.|:....
Human   465 KAFSQKSYLMLHQRGHTGEKPYECNECEKAFSQKSYLIIHQRTHTE-EKPYKCNECGKAFREKSK 528

  Fly   493 MKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTH 557
            :..|.:.|..|||..|.||.|||:.|..|..|:.:| ..||.:.|..||:|:..:.:..:|||||
Human   529 LIIHQRIHTGEKPYECPVCWKAFSQKSQLIIHQRTH-TGEKPYACTECGKAFREKSTFTVHQRTH 592

  Fly   558 TGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            ||:..|||..|.:.|.....|..| |:.||..:.|
Human   593 TGEKPYKCTECGKAFTQKSNLIVH-QRTHAGKKAH 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	92/339 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF182	NP_001171570.1	KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		COG5048	147..553	CDD:227381	118/428 (28%)
		C2H2 Zn finger	209..228	CDD:275368	6/18 (33%)
		C2H2 Zn finger	236..256	CDD:275368	2/20 (10%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	277..299	CDD:290200	7/21 (33%)
		C2H2 Zn finger	292..312	CDD:275368	5/19 (26%)
		zf-H2C2_2	308..329	CDD:290200	7/20 (35%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		zf-H2C2_2	332..357	CDD:290200	7/26 (27%)
		C2H2 Zn finger	348..368	CDD:275368	6/21 (29%)
		zf-C2H2	374..396	CDD:278523	9/22 (41%)
		C2H2 Zn finger	376..396	CDD:275368	9/20 (45%)
		zf-H2C2_2	389..412	CDD:290200	12/26 (46%)
		C2H2 Zn finger	404..424	CDD:275368	6/24 (25%)
		zf-H2C2_2	417..441	CDD:290200	6/25 (24%)
		C2H2 Zn finger	432..452	CDD:275368	5/19 (26%)
		zf-H2C2_2	444..469	CDD:290200	4/27 (15%)
		C2H2 Zn finger	460..480	CDD:275368	4/19 (21%)
		zf-H2C2_2	472..497	CDD:290200	5/24 (21%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		zf-H2C2_2	500..523	CDD:290200	8/23 (35%)
		C2H2 Zn finger	516..536	CDD:275368	5/19 (26%)
		zf-H2C2_2	529..553	CDD:290200	11/23 (48%)
		C2H2 Zn finger	544..564	CDD:275368	9/19 (47%)
		zf-H2C2_2	557..579	CDD:290200	8/22 (36%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	587..609	CDD:290200	12/21 (57%)
		C2H2 Zn finger	600..620	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..639		3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010