DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF16

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001025147.2	Gene:	ZNF16 / 7564	HGNCID:	12947	Length:	682	Species:	Homo sapiens

Alignment Length:	430	Identity:	130/430 - (30%)
Similarity:	189/430 - (43%)	Gaps:	52/430 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 SYACKFC---LRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQH 247
            :|.|..|   .|...::...|       :.|..|:||.|.||...|...:|...|.||...||.:
Human   264 AYQCSECGKAFRGHSDFSRHQ-------SHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPY 321

  Fly   248 ACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCER 312
            .|..|||.:....||..|...:..|..:.|:.|.|.|....:|..|.:.|..::.|:|  ..|.:
Human   322 ECNECGKAFRRSSNLIQHQRIHSGEKPYVCSECGKAFRRSSNLIKHHRTHTGEKPFEC--GECGK 384

  Fly   313 LFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASY 377
            .|....||..|:..|:|   .|...|..|||.|..:..|..| :|.|.|||||||::|.:.|:..
Human   385 AFSQSAHLRKHQRVHTG---EKPYECNDCGKPFSRVSNLIKH-HRVHTGEKPYKCSDCGKAFSQS 445

  Fly   378 A----EKRIH-------------------MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSA 419
            :    .:|||                   :|.:|:...|..:...|.:|.:.||....||.|...
Human   446 SSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKHQIIHTGEKPYRCSVCGKAFSHSSALIQHQGV 510

  Fly   420 EHLQRP------GAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDR 476
            ....:|      |.....::..:|.|   |.::|  .::|..|.:.|:..|.|.:|..:|:.. :
Human   511 HTGDKPYACHECGKTFGRSSNLILHQ---RVHTGEKPYECTECGKTFSQSSTLIQHQRIHNGL-K 571

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCG 541
            ||.|..|.|.|.|:.::..|.|.|..|||..|..|||.|:....|.||::.| ..|:.:||:.||
Human   572 PHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIH-TGERPYKCSECG 635

  Fly   542 RAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            :|:.....|..|||.|||...|.|..|.:.|....||..|
Human   636 KAFSQRSVLIQHQRIHTGVKPYDCAACGKAFSQRSKLIKH 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	97/340 (29%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	6/39 (15%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	6/17 (35%)
ZNF16	NP_001025147.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Necessary for transcription activation	62..210
		COG5048	<160..369	CDD:227381	33/111 (30%)
		C2H2 Zn finger	187..203	CDD:275368
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368
		C2H2 Zn finger	267..287	CDD:275368	4/26 (15%)
		Required for nuclear localization	268..393		37/133 (28%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		COG5048	303..675	CDD:227381	116/382 (30%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		Required for nuclear localization	341..373		8/31 (26%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368	6/21 (29%)
		C2H2 Zn finger	407..427	CDD:275368	8/20 (40%)
		C2H2 Zn finger	435..455	CDD:275368	4/19 (21%)
		C2H2 Zn finger	463..483	CDD:275368	2/19 (11%)
		Required for nuclear localization	473..503		7/29 (24%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	4/22 (18%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	603..623	CDD:275368	8/19 (42%)
		C2H2 Zn finger	631..651	CDD:275368	8/19 (42%)
		C2H2 Zn finger	659..679	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100