DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF8

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_066575.2	Gene:	ZNF8 / 7554	HGNCID:	13154	Length:	575	Species:	Homo sapiens

Alignment Length:	439	Identity:	106/439 - (24%)
Similarity:	171/439 - (38%)	Gaps:	74/439 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 CQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIF 144
            ||...|.|.      :.::|:..|.|.::....::..:|...:....:|:...|
Human   143 CQSQSLALK------EQNNLKQLEFGLKEAPVQDQGYKTLRLRENCVLSSSPNP----------- 190

  Fly   145 VDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQL-----QQL 204
                     ..|....|....||.::.:...:.|...|.|.|..    .:|.||...     |.:
Human   191 ---------FPEISRGEYLYTYDSQITDSEHNSSLVSQQTGSPG----KQPGENSDCHRDSSQAI 242

  Fly   205 LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKY 269
            .:..:..|...::||.|.:|...|...|..|||.:....|:.:.|..|||.:....:|..|...:
Human   243 PITELTKSQVQDKPYKCTDCGKSFNHNAHLTVHKRIHTGERPYMCKECGKAFSQNSSLVQHERIH 307

  Fly   270 HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            ..:..::||.|.|.|.....|..|.:.|..::.::|:  .|.|.|.....|..|:.||:|   .|
Human   308 TGDKPYKCAECGKSFCHSTHLTVHRRIHTGEKPYECQ--DCGRAFNQNSSLGRHKRTHTG---EK 367

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSE 399
            ...|..|||:|.....|..|: |.|..|:||:|.:|.:.|            ||..:|...:|..
Human   368 PYTCSVCGKSFSRTTCLFLHL-RTHTEERPYECNHCGKGF------------RHSSSLAQHQRKH 419

  Fly   400 C----MLCRQP--FSSEPDLIHHMSAEHLQRPGA-PIIANNKRVLQQKRERQYSGLFQCGSCSQR 457
            .    ..|||.  |...|.|..|...|.|   |. |.::.::|..:..|.      |:|..|.:.
Human   420 AGEKPFECRQRLIFEQTPALTKHEWTEAL---GCDPPLSQDERTHRSDRP------FKCNQCGKC 475

  Fly   458 FNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPN 506
            |...|.|.||...|:.:::||.   .|:|.:::.....|:..|  :.||
Human   476 FIQSSHLIRHQITHTREEQPHG---RSRRREQSSSRNSHLVQH--QHPN 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	3/6 (50%)
		COG5048	198..>508	CDD:227381	86/321 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/25 (28%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	3/19 (16%)
		C2H2 Zn finger	508..528	CDD:275368
		C2H2 Zn finger	537..557	CDD:275368
		C2H2 Zn finger	565..582	CDD:275368
ZNF8	NP_066575.2	KRAB	25..85	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..130
		COG5048	<167..404	CDD:227381	64/266 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..237		7/30 (23%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		C2H2 Zn finger	343..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..391	CDD:275368	8/20 (40%)
		zf-C2H2	397..419	CDD:306579	8/33 (24%)
		C2H2 Zn finger	399..419	CDD:275368	7/31 (23%)
		zf-C2H2	467..489	CDD:306579	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..533		9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100