DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp820

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_083557.2	Gene:	Zfp820 / 75424	MGIID:	1922674	Length:	549	Species:	Mus musculus

Alignment Length:	529	Identity:	134/529 - (25%)
Similarity:	222/529 - (41%)	Gaps:	85/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 HIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSA-----------ETQPNN---TASD 139
            |.:..|...|.:..|:|:      ..|:.|::|...|.:.|           ||:.|.   .:..
Mouse    74 HEHVNIQVKSYKCHELGK------IIHESTQSTPYKTNLRATSVESSNLSRHETENNREPCKSKS 132

  Fly   140 PIEI--FVDAVDIDEAEEEEEEE----EQQQQYD--EEVEEPITDESAPPQLTISYACKFCLRPQ 196
            |:..  ....:.:.:.....::|    |..:.:|  ::::...|:....|     |.|..|   .
Mouse   133 PVNCLNLFSTISLTQGIHRRKKEYYGTELVKVFDSKQKLKLKQTNNREKP-----YKCSEC---D 189

  Fly   197 ENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHN 261
            :.:..:..|.:| ...|..|:||.|.||:..|.......:|.:....||.:.|..|.|.:..:..
Mouse   190 KCFTKKCKLRQH-QRIHTGEKPYKCSECDKCFTQKDRLIIHQRVHTGEKPYKCSECDKGFTSKSR 253

  Fly   262 LRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEAT 326
            |..|...:..|..::|:.|:|.|..:.:|:.|::.|..::.:||  |.|::.|..:..|..|:..
Mouse   254 LNIHQRVHTGEKSYKCSECDKSFSQQGNLSIHLRIHTGEKPYKC--SECDKCFTYKSGLRSHQII 316

  Fly   327 HSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHREN 391
            |:|   .|:..|..|||.|.|...||.| ...|.|||||||:.|.:.|.......||.:..
Mouse   317 HTG---EKAYKCSECGKCFTHKGDLRRH-QSIHMGEKPYKCSECDKGFTQKCRLIIHQIIH---- 373

  Fly   392 LTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQ 456
             |..:..:|..|.:.|..:.||..|......::|                       ::|..|.:
Mouse   374 -TGKKGYKCSECDKCFILKSDLSIHQRIHTGEKP-----------------------YECSECGK 414

  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521
            .|..||.|..|..||: .::.:.|..|.|.|.:..:::.|::.|..|||..|..|.|.|..|..|
Mouse   415 GFTSKSRLNIHQRVHT-GEKSYKCSECDKSFTQQGNLRIHLRIHTGEKPYKCSECDKCFTYKSGL 478

  Fly   522 TQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            ..|::.| ..||.:||:.||:.:..:..||.||..|.|:..|||..|.:.|..  |:.::
Mouse   479 RSHQIIH-TGEKAYKCSECGKCFTHKGDLRRHQSVHMGEKPYKCSECDKGFTQ--KMPSY----- 535

  Fly   587 AASQPHSAD 595
                 ||:|
Mouse   536 -----HSSD 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	83/309 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp820	NP_083557.2	KRAB	13..>55	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	163..513	CDD:227381	107/394 (27%)
		C2H2 Zn finger	185..205	CDD:275368	4/23 (17%)
		zf-H2C2_2	198..222	CDD:290200	10/24 (42%)
		C2H2 Zn finger	213..233	CDD:275368	5/19 (26%)
		zf-H2C2_2	226..250	CDD:290200	6/23 (26%)
		C2H2 Zn finger	241..261	CDD:275368	5/19 (26%)
		zf-H2C2_2	254..278	CDD:290200	7/23 (30%)
		C2H2 Zn finger	269..289	CDD:275368	6/19 (32%)
		zf-H2C2_2	281..306	CDD:290200	8/26 (31%)
		C2H2 Zn finger	297..317	CDD:275368	6/21 (29%)
		zf-H2C2_2	310..334	CDD:290200	10/26 (38%)
		C2H2 Zn finger	325..345	CDD:275368	9/20 (45%)
		zf-H2C2_2	337..362	CDD:290200	13/25 (52%)
		C2H2 Zn finger	353..373	CDD:275368	5/19 (26%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	393..418	CDD:290200	7/47 (15%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		zf-H2C2_2	422..446	CDD:290200	8/24 (33%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		zf-H2C2_2	449..474	CDD:290200	9/24 (38%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		zf-H2C2_2	478..502	CDD:290200	9/24 (38%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
		zf-H2C2_2	505..530	CDD:290200	11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100