DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp943

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001020544.1	Gene:	Zfp943 / 74670	MGIID:	1921920	Length:	507	Species:	Mus musculus

Alignment Length:	517	Identity:	137/517 - (26%)
Similarity:	209/517 - (40%)	Gaps:	122/517 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 AVDIDEAEEEEEEEEQQQQY-DEEVE-----------------EPITDESAPPQLTI-------S 186
            |||..:.|.:..:..|:..| |..:|                 |.|.||..  |..:       |
Mouse    19 AVDFSQDEWKYLDRAQRALYVDVMLENYKNLFFVESHYLTHKYENILDEDT--QCIVHEHMNLQS 81

  Fly   187 YACKFCLRPQENYQLQQLLLEH-----INASH----------------DPEQPYNCPECE----- 225
            |.|         ::|.:|:.||     ..|||                :.::|..|..|.
Mouse    82 YKC---------HELGKLIHEHTQSTSYRASHKNISLESSYVNRHGSMNTKEPCRCKNCVNCLNL 137

  Fly   226 ----ARFQ-------------DAASRTVH---LKSSHV-EKQHACGVCGKKYGDRHNLRHHVEKY 269
                :.:|             |.|..|.|   ||.::. .|.:.|..|.|.:..:.:|..|...:
Mouse   138 CSIISLYQGIHIGQKEHNTELDKAFDTKHELMLKQTNSGNKPYKCSKCDKCFTRKGDLWSHQRIH 202

  Fly   270 HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            ..|..::|:.|:|.|..:..:..|.:.|..::.:||  |.|.:.|..:..|..|:..|:|....|
Mouse   203 TGEKPYKCSKCDKCFTRKGDVIIHERIHTGEKPYKC--SECGKCFTHKGGLRSHQRIHTGGKPYK 265

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSE 399
               |..|.|:|...:.||.| .|.|.|||||||..||:.|....:..||    ||.: |..:..:
Mouse   266 ---CCECIKSFNRKRNLRIH-QRIHTGEKPYKCTECTKCFTRKGDLIIH----HRIH-TGEKPYK 321

  Fly   400 CMLCRQPFSSEPDL-IHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSA 463
            |..|.:.|:.:.|| ||    :.:...|.|                    ::|..|.:.|..|..
Mouse   322 CNECEKCFTVKSDLGIH----QRIHTGGKP--------------------YKCSECVKSFTQKGN 362

  Fly   464 LERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH 528
            |.||..:|: .::|:.|..|:|.|.:...::.|.:.|..|||..|..|.|.|..|..|.:|:..|
Mouse   363 LRRHQRIHT-GEKPYKCSECNKCFTQKDILRRHQRIHTGEKPYKCSECDKCFTQKGDLRRHQRIH 426

  Fly   529 EVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQ 590
             ..||.:||:.|.:.:..:..||:|||.|.|...|.|..|.:.|.....|..| |:.|||.:
Mouse   427 -TGEKPYKCSECDKCFALKSELRIHQRIHIGGKLYNCSECDKCFTQKCSLGIH-QRTHAAEK 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/357 (25%)
		C2H2 Zn finger	221..241	CDD:275368	9/44 (20%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	7/20 (35%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp943	NP_001020544.1	KRAB	13..>55	CDD:214630	8/35 (23%)
		KRAB	13..52	CDD:279668	8/32 (25%)
		COG5048	<74..323	CDD:227381	67/268 (25%)
		C2H2 Zn finger	182..202	CDD:275368	5/19 (26%)
		zf-H2C2_2	194..219	CDD:290200	7/24 (29%)
		C2H2 Zn finger	210..230	CDD:275368	5/19 (26%)
		zf-H2C2_2	226..247	CDD:290200	7/22 (32%)
		C2H2 Zn finger	238..258	CDD:275368	6/21 (29%)
		COG5048	<246..482	CDD:227381	83/271 (31%)
		C2H2 Zn finger	266..286	CDD:275368	8/20 (40%)
		zf-H2C2_2	278..303	CDD:290200	15/25 (60%)
		C2H2 Zn finger	294..314	CDD:275368	8/23 (35%)
		C2H2 Zn finger	322..342	CDD:275368	7/23 (30%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..387	CDD:290200	9/25 (36%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		zf-H2C2_2	391..415	CDD:290200	9/23 (39%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		zf-H2C2_2	418..442	CDD:290200	8/24 (33%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	462..482	CDD:275368	6/20 (30%)
		C2H2 Zn finger	490..506	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100