DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp433

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_011241889.1	Gene:	Zfp433 / 73610	MGIID:	1920860	Length:	619	Species:	Mus musculus

Alignment Length:	589	Identity:	155/589 - (26%)
Similarity:	244/589 - (41%)	Gaps:	126/589 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DEIGQEDLEPAEEHQE---TETTKPT--TTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEE 161
            |.:..||:.....|:|   .::::.:  ..|..||..|.||            |....|:...||
Mouse    21 DAVTYEDVHVNFSHEEWALLDSSQKSLYRDVMLETYWNLTA------------IGYKLEDPNVEE 73

  Fly   162 QQQQYDE--------------------------------EVEEPITDESAPPQLTISYACKFCLR 194
            ..|.|..                                ::.:.|..|..|      |.|..|.:
Mouse    74 YYQSYRRHRRYNICHCGYKPCEHKGYGKNQYIFACNNFLQIYDRIQTEEKP------YGCSQCSK 132

  Fly   195 PQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDR 259
            ...|:   :.|.:| ..:|..|:||.|.:|...|...:|..:|.::...||.:.|..|||.:..|
Mouse   133 AFANF---RSLRKH-EKNHTREKPYECSQCSKAFVSRSSLQIHERTHTREKLYDCNECGKAFSTR 193

  Fly   260 HNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR------------------ 306
            .:|:.|...:..|..::|:.|.|.|....:|..|.:.|..::.:.|.
Mouse   194 SHLQIHKRTHTGEKPYDCSECGKAFARSSALLIHKRSHTGEKPYGCNECGKAFACRSHLQIHKRT 258

  Fly   307 HSG--------CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEK 363
            |:|        |.:.|.::|||..||.||:|   .|...|..|||.||....|:.| .|.|.|||
Mouse   259 HTGEKPYDCDECGKAFATRRHLQIHERTHTG---EKPYECNQCGKAFIGRSHLQIH-KRVHTGEK 319

  Fly   364 PYKCANCTEVFASYAEKRIH-----------------------MLERHRENLTAIERSECMLCRQ 405
            ||:|..|.:.||..::...|                       .|..|.|:.|..:..||.||.:
Mouse   320 PYECNQCGKAFAYNSDLHRHEIIHTGEKPYGCNQCGKAFANRSSLRNHEEHHTLEKPYECTLCGK 384

  Fly   406 PFSSEPDLIHHMSAEHLQRPGAPIIANN------KRVLQQKRERQYSG--LFQCGSCSQRFNMKS 462
            .|:...:|..|   |.......|.:...      :|......||.::|  .:.|..|.:.|..:|
Mouse   385 AFAYCSNLYIH---ERCHTGEKPYVCTQCGKAFARRSHLHIHERCHTGEKPYVCTQCGKAFARRS 446

  Fly   463 ALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLS 527
            .|..|..:|: .::|:.|..|.|.|.....:..|.:||..|||.||:.||||||.:..|..|..|
Mouse   447 HLHVHERIHA-GEKPYECNQCGKAFLLRSSLLIHERTHTGEKPYVCNQCGKAFARQSHLQIHERS 510

  Fly   528 HEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            | ..||.::||.|.:|::...:|::|:|||||:..|:|:.|.:.|.....|:.| :::|:..:|:
Mouse   511 H-TGEKPYECNQCSKAFVCRSNLQMHERTHTGERPYECNQCGKAFSRRSLLQKH-ERSHSGEKPY 573

  Fly   593 SADQ 596
            :.:|
Mouse   574 ACNQ 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	98/366 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	10/47 (21%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/39 (13%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp433	XP_011241889.1	KRAB	23..63	CDD:396083	10/51 (20%)
		C2H2 Zn finger	127..147	CDD:275368	5/23 (22%)
		zf-H2C2_2	139..164	CDD:404364	9/25 (36%)
		C2H2 Zn finger	155..175	CDD:275368	5/19 (26%)
		COG5048	179..594	CDD:227381	119/409 (29%)
		C2H2 Zn finger	183..203	CDD:275368	7/19 (37%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..259	CDD:275368	1/19 (5%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	9/20 (45%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..367	CDD:275368	1/15 (7%)
		C2H2 Zn finger	379..399	CDD:275368	7/22 (32%)
		C2H2 Zn finger	407..427	CDD:275368	3/19 (16%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	491..511	CDD:275368	9/19 (47%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		C2H2 Zn finger	547..567	CDD:275368	5/20 (25%)
		C2H2 Zn finger	575..595	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010