DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp942

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001185977.1	Gene:	Zfp942 / 73233	MGIID:	1920483	Length:	486	Species:	Mus musculus

Alignment Length:	404	Identity:	112/404 - (27%)
Similarity:	182/404 - (45%)	Gaps:	52/404 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 CKF-----CLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHV-EKQH 247
            ||:     ||.......|.|.|       |..::.:|.......|.  :.:.:.||.::. :|.:
Mouse   128 CKYKNCVNCLNLCSTIGLNQGL-------HIGKKEHNGTVLNKVFD--SKQILGLKQTNSGKKPY 183

  Fly   248 ACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCER 312
            .|..|.:.:..:..||.|...:..|..::|:.|:|.|:.:.||:.|.::|..::.:||  |.|::
Mouse   184 RCSECSRCFTKKCKLRQHQTIHTGEKPYKCSECDKCFFYKYSLSIHQRFHTSEKLYKC--SECDK 246

  Fly   313 LFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASY 377
            .|..:..|..|:..|:|   .|...|..|.|:|.....||.| .|.|.|||||||:.|.:.|..
Mouse   247 CFTFKSVLRIHQRIHTG---EKPYKCSKCEKSFTRKSNLRIH-QRIHTGEKPYKCSECDKCFTF- 306

  Fly   378 AEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRE 442
              |..|.:  |:...|..:..:|..|.:.|:.:..|..|......::|
Mouse   307 --KNTHRI--HQRIHTGEKPYKCSECEKSFTRKSHLRIHQRIHTGEKP----------------- 350

  Fly   443 RQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNV 507
                  ::|..|.:.|..:..|..|..:|:.: :|:.|..|.|.|.|..::..|.|.|..|||..
Mouse   351 ------YKCSECDKCFTYEHTLSNHQRIHTGQ-KPYKCSECDKCFTRKCNLIIHQKIHTGEKPYK 408

  Fly   508 CDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERF 572
            |..|.|.|..|..|:.|:::| ..||.:||:.|.:.:..:..||.|||.|:|:..|||..|.:.|
Mouse   409 CSECDKCFTHKGGLSIHQITH-TGEKPYKCSECNKCFTHKGDLRRHQRIHSGEKPYKCSECDKCF 472

  Fly   573 VTHIKLKTHMQKAH 586
            .....|::| |:.|
Mouse   473 TRKFSLRSH-QRIH 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	79/310 (25%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp942	NP_001185977.1	KRAB	15..52	CDD:366587
		C2H2 Zn finger	185..205	CDD:275368	5/19 (26%)
		zf-H2C2_2	198..220	CDD:372612	7/21 (33%)
		C2H2 Zn finger	213..233	CDD:275368	7/19 (37%)
		COG5048	<237..397	CDD:227381	50/194 (26%)
		C2H2 Zn finger	241..261	CDD:275368	6/21 (29%)
		C2H2 Zn finger	269..289	CDD:275368	8/20 (40%)
		C2H2 Zn finger	297..317	CDD:275368	6/24 (25%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	353..373	CDD:275368	5/19 (26%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		SFP1	<403..481	CDD:227516	29/78 (37%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	465..485	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100