DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF878

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_016882684.1	Gene:	ZNF878 / 729747	HGNCID:	37246	Length:	567	Species:	Homo sapiens

Alignment Length:	553	Identity:	149/553 - (26%)
Similarity:	235/553 - (42%)	Gaps:	88/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NAFRLACQEAQLKLSHIYDKIDASSLEDDE----------IGQEDLEPAEEHQETE--TTKPTTT 126
            |.:|...||....|:.|..|.:...:||:.          ||:...|..|.||..|  |..|..|
Human    63 NLYREVMQETLRNLTSIGKKWNNQYIEDEHQNPRRNLRRLIGERLSESKESHQHGEVLTQVPDDT 127

  Fly   127 VSAETQPNNTASDPI--EIFVDAVDID---------------------EAEEEEEEEEQQQQYDE 168
            :..:|....:....:  ||.:....::                     |...|.:|..:..::..
Human   128 LKKKTPGVQSYESSVCGEIGIGLSSLNRHLRAFSYSSSLAIHGRTHTGEKPYECKECGKAFRFPS 192

  Fly   169 EV--EEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDA 231
            .|  .|.|.....|      |.||.|   .:.:.....:..| ...|..::||.|.:|.......
Human   193 SVRRHERIHSAKKP------YECKQC---GKAFSFPSSVRRH-ERIHSAKKPYECKQCGKALSYL 247

  Fly   232 ASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKW 296
            .|...|::....|:.|.|.:|||.:....:|:.|.:.:..|..::|..|:|.|....|..||.:.
Human   248 VSFQTHMRMHTGERPHKCNICGKAFFSPSSLKRHEKSHTGEKRYKCKQCDKAFNCPSSFQYHERT 312

  Fly   297 HNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGG 361
            |:.::.::|  :.|.:.|.|.::|..||..|:|   .|...|..|||.||...:.|:| .:.|.|
Human   313 HSGEKPYEC--TQCRKAFRSVKYLRVHERKHTG---EKPYECKLCGKGFISSTSFRYH-EKTHTG 371

  Fly   362 EKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPG 426
            ||||:|..|.:.|:...:.|||  ||..   |..:..||..|.:.|:|.....:|
Human   372 EKPYECKKCVKAFSFVKDLRIH--ERTH---TGEKPFECKQCGKTFTSSNSFHYH---------- 421

  Fly   427 APIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKR 489
                           ||.::|  .::|..|.:.|...|.|::|...|: .::|:.|..|.|.|:.
Human   422 ---------------ERTHTGEKPYECKQCGKAFRSASVLQKHIRTHT-GEKPYGCKQCGKVFRV 470

  Fly   490 AQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQ 554
            |..:|.|.:||..|||..|..|||||.....:..|:.:| ..||.:||..||:|::...|...|:
Human   471 ASQLKMHERTHTGEKPYECKQCGKAFISSNSIRYHKRTH-TGEKPYKCKQCGKAFISSNSFLYHE 534

  Fly   555 RTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHA 587
            |.|||:..|:|..|.:.|.:...|:.|: :.||
Human   535 RIHTGEKPYECKQCGKAFRSASILQKHV-RTHA 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	4/12 (33%)
		COG5048	198..>508	CDD:227381	87/311 (28%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF878	XP_016882684.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910