DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp493

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_082678.2	Gene:	Zfp493 / 72958	MGIID:	1920208	Length:	384	Species:	Mus musculus

Alignment Length:	448	Identity:	115/448 - (25%)
Similarity:	171/448 - (38%)	Gaps:	83/448 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 AVDIDEAEEEEEEEEQQQQYDEEVEEPITD-------ESAPPQLTISYACKFCLRPQE-NYQLQQ 203
            |:|....|.|..:..|...|.|.:.|..:.       .|.|..:|....     ||:. |.:.|.
Mouse    11 AIDFSAEERECLDSAQWNLYKEVMLENYSHLVFLGLAFSKPHLITFLER-----RPEPWNVKTQA 70

  Fly   204 LLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEK 268
            .:     .::...:||.|.:|...|...:....|.:....||.:.|..|||.:.....|:.|...
Mouse    71 SV-----GTYPGSKPYQCKQCGKAFGWKSLLVQHQRIHTGEKPYICKECGKAFNYSSTLKQHQRI 130

  Fly   269 YHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSR 333
            :..|..::|.:|:|.|....|...|.:.|..::.:||.
Mouse   131 HTGEKPYKCEVCDKAFKYSFSFKQHQRIHTGEKPYKCE--------------------------- 168

  Fly   334 KSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERS 398
                  .|||.|.....|..| .|.|.|||||:|..|...|.:|:.     |..||:..|.::..
Mouse   169 ------VCGKAFNCSSYLGKH-QRIHTGEKPYRCEECGRAFTNYSG-----LTVHRKVHTGVKPY 221

  Fly   399 ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSA 463
            :|..|.:.||:...|..|......::|                       ::|..|.:.|::.|.
Mouse   222 KCEECGKAFSARTTLSKHHRIHTGEKP-----------------------YKCDECGKTFSVHST 263

  Fly   464 LERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH 528
            ..:|..:|: .::|:.|..|...|.....:..|..||..|||..|..|||||.....|.||:..|
Mouse   264 FSKHQRLHT-GEKPYKCEECGMAFIGRCILSKHRGTHTGEKPYKCKECGKAFNCSSSLHQHQQIH 327

  Fly   529 EVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            .. ||.|||:.||:|:.....|..|:|.|||...|||..|.:.|........| |:.|
Mouse   328 RG-EKLFKCDDCGQAFSCSSYLYKHRRIHTGMKPYKCKECGKAFNCSSSRNQH-QRIH 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	70/309 (23%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	1/21 (5%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp493	NP_082678.2	KRAB	5..65	CDD:214630	13/58 (22%)
		KRAB	5..44	CDD:279668	8/32 (25%)
		C2H2 Zn finger	83..103	CDD:275368	4/19 (21%)
		zf-H2C2_2	96..120	CDD:290200	7/23 (30%)
		C2H2 Zn finger	111..131	CDD:275368	6/19 (32%)
		zf-H2C2_2	124..148	CDD:290200	7/23 (30%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		zf-H2C2_2	151..176	CDD:290200	9/57 (16%)
		C2H2 Zn finger	167..187	CDD:275368	8/53 (15%)
		zf-H2C2_2	179..204	CDD:290200	12/25 (48%)
		COG5048	<191..327	CDD:227381	43/164 (26%)
		C2H2 Zn finger	195..215	CDD:275368	7/24 (29%)
		zf-H2C2_2	208..231	CDD:290200	6/22 (27%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		zf-H2C2_2	236..259	CDD:290200	5/45 (11%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	4/19 (21%)
		zf-H2C2_2	292..316	CDD:290200	12/23 (52%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		zf-H2C2_2	347..372	CDD:290200	11/24 (46%)
		C2H2 Zn finger	363..383	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100