DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp74

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_848471.2	Gene:	Zfp74 / 72723	MGIID:	107784	Length:	679	Species:	Mus musculus

Alignment Length:	564	Identity:	157/564 - (27%)
Similarity:	234/564 - (41%)	Gaps:	98/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EEHQETETTKP----TTTVSAETQPNNTAS------DPIEIFVDAVDIDEAEEEEEEE------- 160
            :|||:.:..:.    ..|..|...|...||      |.|.......:.|...|..|..
Mouse    86 DEHQKIQDGQVFEGIVVTSEASECPEEFASTFFPNADSIPSMHSLFECDGVGECLEPNFGDDDVQ 150

  Fly   161 ----EQQQQYDEEVEEPITDESAPPQLTISYACKFC-------------LRPQ------------ 196
                |:|.:||:.::...|  |:|..:...:.|..|             ||..
Mouse   151 YPLPEEQFEYDDAMQPFHT--SSPHFVLTPFKCNHCGKGFSQTLDLIRHLRVHTGGKLYECHQCG 213

  Fly   197 ENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHN 261
            :.:..::.|:.| :..|..||.|.|.||...|...::...|.:....||.:.|..|||.:|.:.|
Mouse   214 KGFSHKEKLINH-HKLHSREQCYECSECGKTFIKMSNLIRHQRIHTGEKPYVCQECGKSFGQKSN 277

  Fly   262 LRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEA 325
            |..| ||.|: |..::|..|.|.|..::||..|.|.|..::.:.|..  |.:.|.....|..|..
Mouse   278 LIDH-EKIHTGEKPYKCNECGKSFSQKQSLVAHQKVHTGEKPYACNE--CGKAFPRVASLALHMR 339

  Fly   326 THSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRE 390
            .|:|   .|...|..|||.|.....|..|: |.|.|||||:|..|.:.|:..:...:| :..|
Mouse   340 GHTG---EKPYKCDKCGKAFSQFSMLIIHV-RVHTGEKPYECGECGKAFSQSSALTVH-IRSH-- 397

  Fly   391 NLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQKRERQYSG-- 447
              |..:..||..||:.||.:.:.|.|......::|      |...|..:..|   :.:|.::|
Mouse   398 --TGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGCNECGKAFIQMSNLV---RHQRIHTGEK 457

  Fly   448 LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCG 512
            .:.|..|.:.|:.||.|..|..:|| .::|:.|..|.|.|.:.|:...|.|.|..|||..|:.||
Mouse   458 PYLCKECGKAFSQKSNLIAHEKIHS-GEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNKCG 521

  Fly   513 KAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIK 577
            |||:....||.|..|| ..||.::|..||:|:.....|.||.|:|||:..|.|:.|.:.|.....
Mouse   522 KAFSQIASLTLHLRSH-TGEKPYECEKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTS 585

  Fly   578 LKTHMQKAHAASQP----------------------HSADQPLD 599
            |..|| :.|...:|                      |:.::|.|
Mouse   586 LIVHM-RGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFD 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	97/318 (31%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	9/19 (47%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp74	NP_848471.2	KRAB	8..68	CDD:214630
		C2H2 Zn finger	181..201	CDD:275368	4/19 (21%)
		COG5048	205..638	CDD:227381	133/443 (30%)
		C2H2 Zn finger	209..229	CDD:275368	2/20 (10%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		C2H2 Zn finger	265..285	CDD:275368	10/20 (50%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
		C2H2 Zn finger	321..341	CDD:275368	5/21 (24%)
		C2H2 Zn finger	349..369	CDD:275368	8/20 (40%)
		C2H2 Zn finger	377..397	CDD:275368	4/20 (20%)
		C2H2 Zn finger	405..425	CDD:275368	7/19 (37%)
		C2H2 Zn finger	433..453	CDD:275368	4/22 (18%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	9/19 (47%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	573..593	CDD:275368	6/20 (30%)
		C2H2 Zn finger	601..621	CDD:275368	0/19 (0%)
		C2H2 Zn finger	629..649	CDD:275368	157/564 (28%)
		zf-H2C2_2	641..666	CDD:372612
		C2H2 Zn finger	657..677	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100