DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp932

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_663538.2	Gene:	Zfp932 / 69504	MGIID:	1916754	Length:	526	Species:	Mus musculus

Alignment Length:	504	Identity:	144/504 - (28%)
Similarity:	226/504 - (44%)	Gaps:	59/504 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQ 164
            ||..| :|..|.:..|...|.             |:|...|.|    .:...||.......:.::
Mouse    49 EDSNI-EEHCESSRRHGRHER-------------NHTGEKPYE----GIQYGEAFVHHSSLQMRK 95

  Fly   165 QYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQ 229
            ...       |.|.       .|.|..|   .:.|....:|..| ..:|..|:||.|.:|...|.
Mouse    96 IIH-------TGEK-------RYKCNQC---DKAYSRHSILQIH-KRTHSGEKPYECNQCGKAFT 142

  Fly   230 DAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHM 294
            ..:...:|:.:...||.:.|..|||.:.....|:.|...:..|..:||..|.|.|.....|..|.
Mouse   143 QHSHLKIHMVTHTGEKPYKCDQCGKAFAFHSTLQVHKRTHTGEKPYECNQCSKAFAHHCHLRVHK 207

  Fly   295 KWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQH 359
            :.|..::.:||  ..|.:.|:.|..|..||..|:|   .|...|..|||.|:...:||.| ...|
Mouse   208 RIHTGEKPYKC--DQCGKAFVGQNDLKRHERVHTG---EKPYKCNECGKAFVCNASLRTH-KTTH 266

  Fly   360 GGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQR 424
            .|.|||:|..||:.|||:.:     |::|....|..:..:|..|.:.|:|......|......::
Mouse   267 TGVKPYECKQCTKSFASHGQ-----LQKHERIHTGEKPYKCDQCGKAFASHDKFQKHERIHIGEK 326

  Fly   425 P-----GAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPH 482
            |     .....|::.::  ||.||.::|  .::|..|::.|...:.|::|..:|: .::|:.|..
Mouse   327 PYKCKQCTKSFASHDKL--QKHERIHTGEKPYECKQCTKSFASHNKLQKHERIHT-GEKPYKCDQ 388

  Fly   483 CSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFE 547
            |:|.|.....::.|.|||..|||..|:.||||||....|..|:::| ..||.:|||.||:|..:.
Mouse   389 CNKAFVYESYLQVHKKTHTGEKPYKCNECGKAFARHSHLKVHKITH-TGEKPYKCNQCGKALAYH 452

  Fly   548 KSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            .:|::|||||||:..|:|:.|.:.|......:.| ::.|...:|:..||
Mouse   453 STLQVHQRTHTGEKPYECEQCGKAFANQSYFQVH-KRIHTGEKPYKCDQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/316 (29%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	6/16 (38%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp932	NP_663538.2	KRAB	5..45	CDD:366587
		C2H2 Zn finger	82..98	CDD:275368	2/15 (13%)
		COG5048	84..487	CDD:227381	128/436 (29%)
		C2H2 Zn finger	106..126	CDD:275368	5/23 (22%)
		C2H2 Zn finger	134..154	CDD:275368	4/19 (21%)
		C2H2 Zn finger	162..182	CDD:275368	6/19 (32%)
		C2H2 Zn finger	190..210	CDD:275368	6/19 (32%)
		C2H2 Zn finger	218..238	CDD:275368	7/21 (33%)
		C2H2 Zn finger	246..266	CDD:275368	8/20 (40%)
		C2H2 Zn finger	274..294	CDD:275368	8/24 (33%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	5/21 (24%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		C2H2 Zn finger	470..490	CDD:275368	4/20 (20%)
		zf-H2C2_2	482..506	CDD:372612	5/20 (25%)
		C2H2 Zn finger	498..518	CDD:275368	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010