DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF354A

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_005640.2	Gene:	ZNF354A / 6940	HGNCID:	11628	Length:	605	Species:	Homo sapiens

Alignment Length:	587	Identity:	152/587 - (25%)
Similarity:	221/587 - (37%)	Gaps:	142/587 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQ----PNNTASDPIEIFVDAVDIDEAEE 155
            |...:|.|..|...|.....|   :|||.|.|..:..|    ..:..:.|.::.::...|.|...
Human    71 DPWEVEKDGSGVSSLGSKSSH---KTTKSTQTQDSSFQGLILKRSNRNVPWDLKLEKPYIYEGRL 132

  Fly   156 EEEEE-------------------------EQQQQYDEEV----EEPITDESAPPQLTIS----- 186
            |::::                         |..|.:..:.    ::.:..|..||:..|.
Human   133 EKKQDKKGSFQIVSATHKKIPTIERSHKNTELSQNFSPKSVLIRQQILPREKTPPKCEIQGNSLK 197

  Fly   187 ----------------YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRT 235
                            |.|..|   ::.:.....|.:| ..:|..|:.:.|.||...|..:::..
Human   198 QNSQLLNQPKITADKRYKCSLC---EKTFINTSSLRKH-EKNHSGEKLFKCKECSKAFSQSSALI 258

  Fly   236 VHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWH--- 297
            .|..:...||.:.|..|||.:....:|..|:..:..|..:.|..|.|.|..|..|..|.|.|
Human   259 QHQITHTGEKPYICKECGKAFTLSTSLYKHLRTHTVEKSYRCKECGKSFSRRSGLFIHQKIHAEE 323

  Fly   298 -----NPDRQ-FKCRH--SGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWH 354
                 ||.|: ..|..  |||:|:.                |.:||..|..||.||....:||:|
Human   324 NPCKYNPGRKASSCSTSLSGCQRIH----------------SRKKSYLCNECGNTFKSSSSLRYH 372

  Fly   355 IYRQHGGEKPYKCANCTEVFASYA----EKRIH-------------------MLERHRENLTAIE 396
             .|.|.||||:||:.|...|:..|    .:|||                   .|.|||...|..:
Human   373 -QRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEK 436

  Fly   397 RSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFN 459
            ...|..|.:..||...||.|                         ||.::|  ..:|..|.:.|.
Human   437 FYNCNECGKALSSHSTLIIH-------------------------ERIHTGEKPCKCKVCGKAFR 476

  Fly   460 MKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQH 524
            ..|||.:|..:|: .:||:.|..|.|.|:....:..|.:.|..|||..|:.||.:|.....|.||
Human   477 QSSALIQHQRMHT-GERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYRCEECGISFGQSSALIQH 540

  Fly   525 RLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAAS 589
            |..| ..||.||||.||:.:....|...|||.|||:..|:|:.|.:.| .|....|:..|.|...
Human   541 RRIH-TGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLF-NHRSSLTNHYKIHIEE 603

  Fly   590 QP 591
            .|
Human   604 DP 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	94/345 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/23 (22%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	7/39 (18%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF354A	NP_005640.2	KRAB	14..73	CDD:214630	1/1 (100%)
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..106		10/34 (29%)
		C2H2 Zn finger	189..208	CDD:275368	1/18 (6%)
		COG5048	198..600	CDD:227381	128/450 (28%)
		C2H2 Zn finger	216..236	CDD:275368	4/23 (17%)
		zf-H2C2_2	228..253	CDD:290200	8/25 (32%)
		C2H2 Zn finger	244..264	CDD:275368	5/19 (26%)
		zf-H2C2_2	256..280	CDD:290200	7/23 (30%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		zf-H2C2_2	284..309	CDD:290200	7/24 (29%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	356..376	CDD:275368	9/20 (45%)
		zf-H2C2_2	368..393	CDD:290200	13/25 (52%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		zf-H2C2_2	396..421	CDD:290200	3/24 (13%)
		C2H2 Zn finger	412..432	CDD:275368	4/19 (21%)
		C2H2 Zn finger	440..460	CDD:275368	9/44 (20%)
		zf-H2C2_2	453..477	CDD:290200	9/48 (19%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		zf-H2C2_2	480..505	CDD:290200	10/25 (40%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		zf-H2C2_2	508..531	CDD:290200	8/22 (36%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		zf-H2C2_2	536..561	CDD:290200	13/25 (52%)
		C2H2 Zn finger	552..572	CDD:275368	8/19 (42%)
		zf-H2C2_2	568..589	CDD:290200	10/21 (48%)
		C2H2 Zn finger	580..600	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100